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Information Journal Paper

Title

Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population

Pages

  214-219

Abstract

 Aim: The aim of this study was to find the relationship between rs1799964 in TNF-α gene as well as rs1051208 of RAF1 gene SNPs on GC in an Iranian population. Background: Gastric cancer (GC) is the second leading cause of cancer-related death worldwide after lung cancer. Tumor necrosis factor (TNF) is one of the most important factors in the pathogenesis of this cancer. Single nucleotide polymorphisms have a principle role in gene expression of TNF-α and miRNAs which may lead to Gastric cancer. Methods: In a case-control study, we investigated the risk of GC in 198 Iranians. For this purpose, 5 mL of peripheral blood was collected in EDTA – containing tube and genomic DNA was isolated. Genotyping of SNPs was also performed by PCR-RFLP; to approve the outcome, 10% of genotyping results with RFLP were sequenced. Results: The comparison between case and control groups revealed a significant association between the rs1051208 C allele of RAF1 gene and GC (P = 0. 04). We did not observe any remarkable association between TNF-α-1031 in Gastric cancer patients and the healthy control group. Conclusion: The results indicated that C allele in RAF1 gene plays a role in susceptibility to Gastric cancer. Therefore, SNPs are among notable biomarkers for predicting susceptibility to dreadful diseases, especially cancers.

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    APA: Copy

    BARADARAN GHAVAMI, SHAGHAYEGH, Chaleshi, Vahid, DERAKHSHANI, SHAGHAYEGH, Aimzadeh, Pedram, ASADZADEH AGHDAEI, HAMID, & ZALI, MOHAMMAD REZA. (2017). Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(3), 214-219. SID. https://sid.ir/paper/324857/en

    Vancouver: Copy

    BARADARAN GHAVAMI SHAGHAYEGH, Chaleshi Vahid, DERAKHSHANI SHAGHAYEGH, Aimzadeh Pedram, ASADZADEH AGHDAEI HAMID, ZALI MOHAMMAD REZA. Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(3):214-219. Available from: https://sid.ir/paper/324857/en

    IEEE: Copy

    SHAGHAYEGH BARADARAN GHAVAMI, Vahid Chaleshi, SHAGHAYEGH DERAKHSHANI, Pedram Aimzadeh, HAMID ASADZADEH AGHDAEI, and MOHAMMAD REZA ZALI, “Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. 3, pp. 214–219, 2017, [Online]. Available: https://sid.ir/paper/324857/en

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