Evaluation of MALAT1 promoter DNA methylation patterns in early colorectal lesions and tumors

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Chaleshi Vahid; IRANI SHIVA; ALEBOUYEH MASOUD; MIRFAKHRAIE REZA; ASADZADEH AGHDAEI HAMID

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:suppl 1 Page(s): 58-65

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Title

Evaluation of MALAT1 promoter DNA methylation patterns in early colorectal lesions and tumors

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Keywords

Long non-coding RNAs

Colorectal cancer

Colonic polyps

Metastasis-associated lung adenocarcinoma transcript 1

MALAT1

DNA Methylation

Abstract

Aim: This study set out to determine the effect of methylation on MALAT1 gene in primary colorectal lesions and tumors to gain further knowledge about the diagnostic and prognostic value of MALAT. Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the Long non-coding RNAs that plays an important role in invasion, cell proliferation, and metastasis of various cancers. However, there is insufficient information on the association between MALAT1 and the methylation process as well as its role in the development of Colorectal cancer. Methods: Methylation pattern of MALAT1 promoter was determined by Methylation-Specific Polymerase Chain Reaction (MSP) in 86 colorectal primary lesions, tumors, and normal specimens. MALAT1 methylation pattern was compared in tumor and polyp tissue. In order to obtain more accurate results, we investigated the association between MALAT1 promoter methylation pattern and clinicopathologic factors in patients. Results: The results indicated that the MALAT1 promoter methylation pattern in the tumor tissue, primary lesion tissue, and normal was not significantly different (p=0. 430). Comparison of the MALAT1 promoter methylation pattern between polyp types and tumor tissue groups was not significant either (p=0. 437). Surprisingly, the methylation frequency of MALAT1 methylation was significantly higher in colon lesions than in their rectum lesion (p = 0. 035). In addition, no significant hypermethylation of MALAT1 was observed between the other patients’ clinicopathological data in both polyp 46/66 and tumor tissues 20/66. Conclusion: This study dealt with determining the effect of methylation on MALAT1 gene in primary colorectal lesions and tumors to gain further knowledge about the diagnostic and prognostic value of MALAT.

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APA: Copy

Chaleshi, Vahid, IRANI, SHIVA, ALEBOUYEH, MASOUD, MIRFAKHRAIE, REZA, & ASADZADEH AGHDAEI, HAMID. (2019). Evaluation of MALAT1 promoter DNA methylation patterns in early colorectal lesions and tumors. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(suppl 1), 58-65. SID. https://sid.ir/paper/324969/en

Vancouver: Copy

Chaleshi Vahid, IRANI SHIVA, ALEBOUYEH MASOUD, MIRFAKHRAIE REZA, ASADZADEH AGHDAEI HAMID. Evaluation of MALAT1 promoter DNA methylation patterns in early colorectal lesions and tumors. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(suppl 1):58-65. Available from: https://sid.ir/paper/324969/en

IEEE: Copy

Vahid Chaleshi, SHIVA IRANI, MASOUD ALEBOUYEH, REZA MIRFAKHRAIE, and HAMID ASADZADEH AGHDAEI, “Evaluation of MALAT1 promoter DNA methylation patterns in early colorectal lesions and tumors,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. suppl 1, pp. 58–65, 2019, [Online]. Available: https://sid.ir/paper/324969/en

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