COMBINATION OF Q-SWITCHED ND: YAG AND FRACTIONAL ERBIUM: YAG LASERS IN TREATMENT OF MELASMA: A RANDOMIZED CONTROLLED CLINICAL TRIAL

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ALAVI SHIVA; ABOLHASANI EHSAN; ASADI SHARIN; NILFOROUSHZADEH MOHAMMAD ALI

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Journal: JOURNAL OF LASERS IN MEDICAL SCIENCES Year:2017 | Volume:8 | Issue:1 Page(s): 1-6

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Title

COMBINATION OF Q-SWITCHED ND: YAG AND FRACTIONAL ERBIUM: YAG LASERS IN TREATMENT OF MELASMA: A RANDOMIZED CONTROLLED CLINICAL TRIAL

Author(s)

ALAVI SHIVA | ABOLHASANI EHSAN | ASADI SHARIN | NILFOROUSHZADEH MOHAMMAD ALI | Issue Writer Certificate

Keywords

MELASMA

MELANOSIS

LASERS

SOLID-STATE

ERBIUM-DOPED YTTRIUM ALUMINUM GARNET LASERS

NEODYMIUM-DOPED YTTRIUM ALUMINUM GARNET LASERS

Abstract

Introduction: Ablative and nonablative LASERS have been used to treat MELASMA. We aimed to assess and compare the combining Q-switched Nd: YAG laser (QSNYL) and fractional erbium: YAG laser (FEYL) with QSNYL alone in treatment of MELASMA.Methods: This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Women with MELASMA and without a history of keloid formation, hypersensitivity to hydroquinone, or pigmentary changes due to laser therapy were randomly allocated to receive four sessions of either QSNYL-FEYL combination or QSNYL alone. All patients received topical treatment with Kligman’s formula. Before laser therapy and 4 weeks after the last treatment session, patients’ skin was assessed for changes in skin color, melanin content, and erythema intensity of MELASMA lesions quantitatively.Results: Finally, 21 patients in QSNYL-FEYL and 20 in QSNYL group (mean age, 38.57 [5.60] and 42.60 [8.44] years, respectively) completed study. The skin color had become lighter in both groups (mean [SD] percentage change of 56.95 [40.29] and 29.25 [13.20] in QSNYL-FEYL and QSNYL groups, respectively) with significantly better results in QSNYL-FEYL group (P=0.006). Percentage of decrease of melanin content was significantly higher in QSNYL-FEYL group (22.01 [10.67] vs.7.69 [4.75]; P<0.001). After adjustment for baseline values, the post treatment intensity of erythema was significantly lower in QSNYL-FEYL group (P<0.001). The patients reported no adverse events.Conclusion: QSNYL-FEYL was significantly more effective in decreasing melanin content of lesions than QSNYL and led to a lighter skin.

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APA: Copy

ALAVI, SHIVA, ABOLHASANI, EHSAN, ASADI, SHARIN, & NILFOROUSHZADEH, MOHAMMAD ALI. (2017). COMBINATION OF Q-SWITCHED ND: YAG AND FRACTIONAL ERBIUM: YAG LASERS IN TREATMENT OF MELASMA: A RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF LASERS IN MEDICAL SCIENCES, 8(1), 1-6. SID. https://sid.ir/paper/325944/en

Vancouver: Copy

ALAVI SHIVA, ABOLHASANI EHSAN, ASADI SHARIN, NILFOROUSHZADEH MOHAMMAD ALI. COMBINATION OF Q-SWITCHED ND: YAG AND FRACTIONAL ERBIUM: YAG LASERS IN TREATMENT OF MELASMA: A RANDOMIZED CONTROLLED CLINICAL TRIAL. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2017;8(1):1-6. Available from: https://sid.ir/paper/325944/en

IEEE: Copy

SHIVA ALAVI, EHSAN ABOLHASANI, SHARIN ASADI, and MOHAMMAD ALI NILFOROUSHZADEH, “COMBINATION OF Q-SWITCHED ND: YAG AND FRACTIONAL ERBIUM: YAG LASERS IN TREATMENT OF MELASMA: A RANDOMIZED CONTROLLED CLINICAL TRIAL,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 8, no. 1, pp. 1–6, 2017, [Online]. Available: https://sid.ir/paper/325944/en

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