STUDY OF INORGANIC ANTIOXIDANT COMPOUND ASSISTED LOW- LEVEL LASER THERAPY ON HUMAN BREAST CANCER CELLS

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KARKHANEH YOUSEFI FARZANEH; Khorsandi Khatereh; MAGHAMI PARVANEH; Hosseinzadeh Reza

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Journal: JOURNAL OF LASERS IN MEDICAL SCIENCES Year:2018 | Volume:9 | Issue:SUPPL A (9TH WORLD CONGRESS OF SOLA) Page(s): 50-50

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Title

STUDY OF INORGANIC ANTIOXIDANT COMPOUND ASSISTED LOW- LEVEL LASER THERAPY ON HUMAN BREAST CANCER CELLS

Author(s)

KARKHANEH YOUSEFI FARZANEH | Khorsandi Khatereh | MAGHAMI PARVANEH | Hosseinzadeh Reza

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Abstract

Background: Cancer is a major burden of disease worldwide. In many countries, cancer ranks the second most common cause of death following cardiovascular diseases. Breast cancer is considered as one of the main causes of death among women in recent years. The treatment and prevention of cancer have been mentioned by many researchers. Oxidative stress plays an important role in the pathogenesis of numerous disorders and pathophysiological processes including cardiovascular diseases, diabetes, and cancer. Using antioxidants as preventive and therapeutic agents is recommended. In this study, the effect of selenium ions as inorganic antioxidant compound along with low-level laser therapy on human breast cancer cell line MDA-MB-231 was investigated.Methods: Breast cancer cell line MDA-MB-231 was exposed to irradiation with a red laser source (660 nm; power density: 30 mW cm2) and another was kept in the dark for 90 seconds. After treatment with laser, the cells were treated with different concentrations of selenium (0-100 mg/mL) for overnight. The MTT assay was used to determine the cell viability. The morphology of cells was studied using inverted light microscopy. All experiments were repeated three times.Results: The results showed that early treatment with low-level laser and then selenium ions reduced the survival and growth of cells. While with the early treatment with selenium and then low-level laser therapy maintained cell survival, and cell death was not observed.Conclusion: This study showed that low-level laser therapy alone is not able to kill breast cancer cells but along with selenium ions, it reduced the cell viability. The morphological study of the cells using inverted light microscopy has confirmed the MTT results.

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APA: Copy

KARKHANEH YOUSEFI, FARZANEH, Khorsandi, Khatereh, MAGHAMI, PARVANEH, & Hosseinzadeh, Reza. (2018). STUDY OF INORGANIC ANTIOXIDANT COMPOUND ASSISTED LOW- LEVEL LASER THERAPY ON HUMAN BREAST CANCER CELLS. JOURNAL OF LASERS IN MEDICAL SCIENCES, 9(SUPPL A (9TH WORLD CONGRESS OF SOLA)), 50-50. SID. https://sid.ir/paper/326106/en

Vancouver: Copy

KARKHANEH YOUSEFI FARZANEH, Khorsandi Khatereh, MAGHAMI PARVANEH, Hosseinzadeh Reza. STUDY OF INORGANIC ANTIOXIDANT COMPOUND ASSISTED LOW- LEVEL LASER THERAPY ON HUMAN BREAST CANCER CELLS. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2018;9(SUPPL A (9TH WORLD CONGRESS OF SOLA)):50-50. Available from: https://sid.ir/paper/326106/en

IEEE: Copy

FARZANEH KARKHANEH YOUSEFI, Khatereh Khorsandi, PARVANEH MAGHAMI, and Reza Hosseinzadeh, “STUDY OF INORGANIC ANTIOXIDANT COMPOUND ASSISTED LOW- LEVEL LASER THERAPY ON HUMAN BREAST CANCER CELLS,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 9, no. SUPPL A (9TH WORLD CONGRESS OF SOLA), pp. 50–50, 2018, [Online]. Available: https://sid.ir/paper/326106/en

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