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Information Journal Paper

Title

Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis

Pages

  125-130

Abstract

 Introduction: Oral Mucositis (OM) is an unavoidable condition of the oral cavity that accompanies chemotherapy for various malignant cases. Chemotherapy-induced Oral Mucositis (COM) is a frequent complication due to mucotoxic drugs and is known to deteriorate the general health significantly, while negatively affecting the quality of life (QOL). Studies have reported that Low-level laser therapy (LLLT) promotes the tissue healing. The objective of the present study was to explore the efficacy of gallium-arsenide (GaAs) laser in treating COM and its impact on inflammatory cytokine levels in patients receiving chemotherapy for various malignancies. Methods: A total of 80 patients with COM received LLLT 6 days/week. OM was graded according to the World Health Organization (WHO) grading scale. The outcome parameters were the serum levels of tumor necrosis factor-alpha (TNF-α ) and interleukin-6 (IL-6) measured before, during and after administration of LLLT. Results: After LLLT, a significant decrease was found in the mean values of mucositis grade from 2. 35 ± 0. 695 to 1. 13 ± 0. 333 after (P < 0. 001). A significant reduction in the level of TNF-α was found after LLLT among breast Cancer patients (P = 0. 0045), but not in head and neck Cancer and lymphoma patients. A significant reduction was also found in IL-6 level after treatment among head and neck and breast Cancer patients (P = 0. 0307 and 0. 019, respectively). Conclusion: The use of GaAs LLLT in treating COM in patients with various malignancies is well tolerated by patients, it results in improvement of mucositis, however; mechanism of action does not seem to be completely linked to the change of pro or anti-inflammatory cytokines.

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    APA: Copy

    Rezk Allah, Soheir Shehata, Abd Elshafi, Heba Mohamed, Farid, Reem Jan, Hassan, Mohamed Abd Elrahman, & Alsirafy, Samy A.. (2019). Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis. JOURNAL OF LASERS IN MEDICAL SCIENCES, 10(2), 125-130. SID. https://sid.ir/paper/326130/en

    Vancouver: Copy

    Rezk Allah Soheir Shehata, Abd Elshafi Heba Mohamed, Farid Reem Jan, Hassan Mohamed Abd Elrahman, Alsirafy Samy A.. Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis. JOURNAL OF LASERS IN MEDICAL SCIENCES[Internet]. 2019;10(2):125-130. Available from: https://sid.ir/paper/326130/en

    IEEE: Copy

    Soheir Shehata Rezk Allah, Heba Mohamed Abd Elshafi, Reem Jan Farid, Mohamed Abd Elrahman Hassan, and Samy A. Alsirafy, “Effect of Low-Level Laser Therapy in Treatment of Chemotherapy Induced Oral Mucositis,” JOURNAL OF LASERS IN MEDICAL SCIENCES, vol. 10, no. 2, pp. 125–130, 2019, [Online]. Available: https://sid.ir/paper/326130/en

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