EFFECT OF BERBERINE ON PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHNIA HAMID REZA; DARBARPANAH SAHAR; HOSEINI SEYED MAHMOOD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2011 | Volume:1 | Issue:2 Page(s): 78-82

Download Full-Text

View:

262

Download:

Cites:

Information Journal Paper

Title

EFFECT OF BERBERINE ON PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS

Author(s)

SADEGHNIA HAMID REZA | DARBARPANAH SAHAR | HOSEINI SEYED MAHMOOD | Issue Writer Certificate

Keywords

BERBERINE

BERBERIS VULGARIS

PENTYLENETETRAZOL

SEIZURE

DIAZEPAM

Abstract

Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have SEIZUREs with current AEDs therapy. Some herbs which traditionally used in the management of SEIZUREs of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the present study was to evaluate the effects of BERBERINE, an alkaloid from BERBERIS VULGARIS, on SEIZUREs induced by PENTYLENETETRAZOL (PTZ) in rats.Material and Methods: Rats (n=6-7) received BERBERINE (100, 200 and 400 mg/kg, i.p.), DIAZEPAM (4mg/kg, i.p. as positive control), and vehicle (saline) and then 30 min later PTZ (110mg/kg, i.p.) were injected. Behavioral responses of the animals to PTZ administration were evaluated using these criteria: latency to first minimal clonic SEIZURE (MCS), incidence of MCS, latency to the first generalized tonic–clonic SEIZUREs (GTCS), incidence of GTCS, protection against GTCS and mortality.Results: Intraperitoneal administration of lower doses of BERBERINE (100 and 200 mg/kg) had no significant effects on minimal clonic SEIZUREs (MCS) and generalized tonic-clonic SEIZUREs (GTCS) latencies, while injection of 400 mg/kg caused significant increase in both MCS and GTCS latencies (p<0.05). In this study DIAZEPAM, (4 mg/kg) 30 min prior to PTZ, significantly increased GTCS latency. BERBERINE at tested doses had no protection against mortality following PTZ administration.Conclusion: It can be concluded that BERBERINE at high doses could be a useful protective agent in PTZ-induced epileptic SEIZUREs in rats.

Cites

No record.

References

No record.

Cite

APA: Copy

SADEGHNIA, HAMID REZA, DARBARPANAH, SAHAR, & HOSEINI, SEYED MAHMOOD. (2011). EFFECT OF BERBERINE ON PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 1(2), 78-82. SID. https://sid.ir/paper/326226/en

Vancouver: Copy

SADEGHNIA HAMID REZA, DARBARPANAH SAHAR, HOSEINI SEYED MAHMOOD. EFFECT OF BERBERINE ON PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2011;1(2):78-82. Available from: https://sid.ir/paper/326226/en

IEEE: Copy

HAMID REZA SADEGHNIA, SAHAR DARBARPANAH, and SEYED MAHMOOD HOSEINI, “EFFECT OF BERBERINE ON PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 1, no. 2, pp. 78–82, 2011, [Online]. Available: https://sid.ir/paper/326226/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops