NEURO-PHARMACOLOGICAL EFFECTS OFCRINUM ZEYLANICUM IN MICE

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TIJANI ADENIYI YAHAYA; SALAWU OLUWAKANYINSOLA ADEOLA; JAIYEOBA GOOD LUCK; ANUKA JOSEPH AKPONSO; HUSSAINI ISAH MARTE

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Journal Paper

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Journal: Avicenna Journal of Phytomedicine Year:2012 | Volume:2 | Issue:3 Page(s): 162-168

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Title

NEURO-PHARMACOLOGICAL EFFECTS OFCRINUM ZEYLANICUM IN MICE

Author(s)

Keywords

CRINUM ZEYLANICUM

PENTOBARBITONE

PSYCHOSIS

SLEEP

STEREOTYPE BEHAVIOUR

Abstract

Objectives: The aim of present study was to evaluate some effects of CRINUM ZEYLANICUM (C. zeylanicum) on central nervous system.Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, PENTOBARBITONE-induced SLEEP test, spontaneous motor activity, apomorphine-induced STEREOTYPE BEHAVIOUR, and rota-rod performance.Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphineinduced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of SLEEP and prolonged the duration of SLEEP. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced STEREOTYPE BEHAVIOURs in mice. The extract had no effect on performance of mice on rotarod.Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties.

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APA: Copy

TIJANI, ADENIYI YAHAYA, SALAWU, OLUWAKANYINSOLA ADEOLA, JAIYEOBA, GOOD LUCK, ANUKA, JOSEPH AKPONSO, & HUSSAINI, ISAH MARTE. (2012). NEURO-PHARMACOLOGICAL EFFECTS OFCRINUM ZEYLANICUM IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(3), 162-168. SID. https://sid.ir/paper/326244/en

Vancouver: Copy

TIJANI ADENIYI YAHAYA, SALAWU OLUWAKANYINSOLA ADEOLA, JAIYEOBA GOOD LUCK, ANUKA JOSEPH AKPONSO, HUSSAINI ISAH MARTE. NEURO-PHARMACOLOGICAL EFFECTS OFCRINUM ZEYLANICUM IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(3):162-168. Available from: https://sid.ir/paper/326244/en

IEEE: Copy

ADENIYI YAHAYA TIJANI, OLUWAKANYINSOLA ADEOLA SALAWU, GOOD LUCK JAIYEOBA, JOSEPH AKPONSO ANUKA, and ISAH MARTE HUSSAINI, “NEURO-PHARMACOLOGICAL EFFECTS OFCRINUM ZEYLANICUM IN MICE,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 3, pp. 162–168, 2012, [Online]. Available: https://sid.ir/paper/326244/en

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