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Information Journal Paper

Title

EFFECT OF CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC, ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS

Pages

  196-205

Abstract

 Objective: CURCUMIN is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of CURCUMIN and DIAZEPAM in separate and combined treatments on PENICILLIN-INDUCED SEIZURES in RATS.Materials and Methods: In urethane-anesthetized RATS, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 ml), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings.Results: Intraperitoneal (i.p.) injections of CURCUMIN at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of DIAZEPAM at a dose of 5 mg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of CURCUMIN (50 mg/kg, i.p.) with DIAZEPAM (5 mg, i.c.v) enhanced the antiepileptic effect of DIAZEPAM (5 mg, i.c.v).Conclusion: The results suggested that both CURCUMIN and DIAZEPAM suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between CURCUMIN and DIAZEPAM in reducing PENICILLIN-INDUCED SEIZURES.

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    APA: Copy

    TAMADDONFARD, ESMAEAL, ERFANPARAST, AMIR, HAMZEH GHOUSHCHI, NASRIN, & YOUSOFIZADEH, SHAHNAZ. (2012). EFFECT OF CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC, ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(4), 196-205. SID. https://sid.ir/paper/326271/en

    Vancouver: Copy

    TAMADDONFARD ESMAEAL, ERFANPARAST AMIR, HAMZEH GHOUSHCHI NASRIN, YOUSOFIZADEH SHAHNAZ. EFFECT OF CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC, ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(4):196-205. Available from: https://sid.ir/paper/326271/en

    IEEE: Copy

    ESMAEAL TAMADDONFARD, AMIR ERFANPARAST, NASRIN HAMZEH GHOUSHCHI, and SHAHNAZ YOUSOFIZADEH, “EFFECT OF CURCUMIN, THE ACTIVE CONSTITUENT OF TURMERIC, ON PENICILLIN-INDUCED EPILEPTIFORM ACTIVITY IN RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 4, pp. 196–205, 2012, [Online]. Available: https://sid.ir/paper/326271/en

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