مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HYDRO-ALCOHOLIC EXTRACT OF THE ROOT OF PRANGOS FERULACEA (L.) LINDL CAN IMPROVE SERUM GLUCOSE AND LIPIDS IN ALLOXAN-INDUCED DIABETIC RATS

Pages

  179-187

Keywords

PRANGOS FERULACEA (L.) LINDL 

Abstract

 Objectives: DIABETES MELLITUS manifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. Previous studies proved that this disease is directly related to hyperglycemia and hyperlipidemia. The aim of this study was to investigate the HYPOGLYCEMIC and HYPOLIPIDEMIC effects of hydroalcoholic extract of Prangos frulacea (L.) Lindl in alloxan-induced diabetic rats.Materials and Methods: Forty female Wistar rats with body weight of 200±20 g were randomly divided into five groups with eight rats per group. Diabetes was induced in rats by alloxan monohydrate at dose of 120 mg/kg body weight (BW) injected intraperitoneally. Hydro-alcoholic extract of the root and leaves with stems of P. frulacea at 100 mg/kg BW were given orally to diabetic rats daily for 4 weeks.Result: Diabetic rats (D) exhibited a significant (p<0.05) increase in the levels of the serum glucose, Total Cholesterol (TC), Triglycerides (TG), and LDL in comparison with the control group whereas their BW and serum HDL levels were decreased. In diabetic rats treated by root extract of P. frulacea, these parameters were reversed to the normal levels compared with diabetic group.Conclusion: According to the results obtained, it was concluded that Root´s hydro-alcoholic extract of P. frulacea can be used in diabetics for the purpose of glucose and LIPID PROFILE reduction.

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    • Cite

    APA: Copy

    KAFASH FARKHAD, NAJME, FAROKHI, FARAH, TUKMACKI, AMIR, & SOLTANI BAND, KHOSRO. (2012). HYDRO-ALCOHOLIC EXTRACT OF THE ROOT OF PRANGOS FERULACEA (L.) LINDL CAN IMPROVE SERUM GLUCOSE AND LIPIDS IN ALLOXAN-INDUCED DIABETIC RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 2(4), 179-187. SID. https://sid.ir/paper/326275/en

    Vancouver: Copy

    KAFASH FARKHAD NAJME, FAROKHI FARAH, TUKMACKI AMIR, SOLTANI BAND KHOSRO. HYDRO-ALCOHOLIC EXTRACT OF THE ROOT OF PRANGOS FERULACEA (L.) LINDL CAN IMPROVE SERUM GLUCOSE AND LIPIDS IN ALLOXAN-INDUCED DIABETIC RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2012;2(4):179-187. Available from: https://sid.ir/paper/326275/en

    IEEE: Copy

    NAJME KAFASH FARKHAD, FARAH FAROKHI, AMIR TUKMACKI, and KHOSRO SOLTANI BAND, “HYDRO-ALCOHOLIC EXTRACT OF THE ROOT OF PRANGOS FERULACEA (L.) LINDL CAN IMPROVE SERUM GLUCOSE AND LIPIDS IN ALLOXAN-INDUCED DIABETIC RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 2, no. 4, pp. 179–187, 2012, [Online]. Available: https://sid.ir/paper/326275/en

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