مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF ALPHA-HEDERIN, THE ACTIVE CONSTITUENT OF NIGELLA SATIVA, ON MIRNA-126, IL-13 MRNA LEVELS AND INFLAMMATION OF LUNGS IN OVALBUMIN-SENSITIZED MALE RATS

Pages

  77-85

Abstract

 Objective: In previous studies the therapeutic effects of Nigella sativa have been demonstrated on ASTHMAtic animals. In the present study, the preventive effect of single dose of ALPHA-HEDERIN, its active constituent, has been evaluated on lung inflammation and some inflammatory mediators in lungs of OVALBUMIN sensitized rat in order to elicit its mechanism.Materials and Methods: Forty rats were randomly grouped in 4 groups; control (C), sensitized (S), sensitized pretreated groups with THYMOQUINONE (3 mg/kg i.p., S+TQ) and ALPHA-HEDERIN (0.02 mg/kg i.p., S+AH). Levels of IL-13 MRNA and MIRNA-126 in lung tissue and its pathological changes in each group were assessed.Results: Elevated levels of MIRNA-126, IL-13 MRNA and pathological changes were observed in the sensitized group compared to the control group (p<0.001 to p<0.05). All of these factors were significantly reduced in S+TQ and S+AH groups in comparison to S group (p<0.001 to p<0.05). Although ALPHA-HEDERIN decreased the levels of MIRNA-126, IL-13 MRNA and pathological changes in comparison with THYMOQUINONE, the results were statistically not significant.Conclusion: The results suggested that ALPHA-HEDERIN had preventive effect on sensitized rats like THYMOQUINONE. It may intervene in MIRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.

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    APA: Copy

    FALLAHI, MARYAM, KEYHANMANESH, RANA, KHAMANEH, AMIR MAHDI, EBRAHIMI SAADATLOU, MOHAMMAD ALI, SAADAT, SAEIDEH, & EBRAHIMI, HADI. (2016). EFFECT OF ALPHA-HEDERIN, THE ACTIVE CONSTITUENT OF NIGELLA SATIVA, ON MIRNA-126, IL-13 MRNA LEVELS AND INFLAMMATION OF LUNGS IN OVALBUMIN-SENSITIZED MALE RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(1), 77-85. SID. https://sid.ir/paper/326313/en

    Vancouver: Copy

    FALLAHI MARYAM, KEYHANMANESH RANA, KHAMANEH AMIR MAHDI, EBRAHIMI SAADATLOU MOHAMMAD ALI, SAADAT SAEIDEH, EBRAHIMI HADI. EFFECT OF ALPHA-HEDERIN, THE ACTIVE CONSTITUENT OF NIGELLA SATIVA, ON MIRNA-126, IL-13 MRNA LEVELS AND INFLAMMATION OF LUNGS IN OVALBUMIN-SENSITIZED MALE RATS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(1):77-85. Available from: https://sid.ir/paper/326313/en

    IEEE: Copy

    MARYAM FALLAHI, RANA KEYHANMANESH, AMIR MAHDI KHAMANEH, MOHAMMAD ALI EBRAHIMI SAADATLOU, SAEIDEH SAADAT, and HADI EBRAHIMI, “EFFECT OF ALPHA-HEDERIN, THE ACTIVE CONSTITUENT OF NIGELLA SATIVA, ON MIRNA-126, IL-13 MRNA LEVELS AND INFLAMMATION OF LUNGS IN OVALBUMIN-SENSITIZED MALE RATS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 1, pp. 77–85, 2016, [Online]. Available: https://sid.ir/paper/326313/en

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