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Information Journal Paper

Title

SAFETY EVALUATION OF PHYTOVAGEX, A PESSARY FORMULATION OF NIGELLA SATIVA, ON PREGNANT RATS (SHORT COMMUNICATION)

Pages

  117-123

Abstract

 Objective: The possible toxicity of drugs in PREGNANCY should be tested before their use in pregnant patients. In the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of NIGELLA SATIVA (N. sativa), which is already in clinical use for vaginal fungal infection.Materials and Methods: The pregnant RATs were treated intravaginal with physiological saline (vehicle) or phytovagex pessary in the first half of their PREGNANCY (days 1 to 10 of gestation). Duration of PREGNANCY and health parameters of the newborns were recorded after parturition. Also, cytotoxicity of N. sativa hydroalcoholic extract was tested against ovary Cho cells.Results: The phytovagex had no significant effect on the duration of PREGNANCY, number of newborns, weight of neonates, and percent of STILLBIRTH. No deformity or general behavioral abnormality was observed in neonates monitored for 30 days after birth. N. sativa extract had no significant effect on the viability of ovary cells at the concentrations of 12.5-200 mg/mL.Conclusion: Results of this animal study showed that phytovagex has no overall effect on the duration of PREGNANCY and health parameters of the newborns. Also, its active agent, N. sativa, does not induce any cytotoxic effect on ovary cells.

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    Cite

    APA: Copy

    SALARINIA, REZA, RAKHSHANDEH, HASSAN, OLIAEE, DAVOOD, GUL GHASEMI, SIMA, & GHORBANI, AHMAD. (2016). SAFETY EVALUATION OF PHYTOVAGEX, A PESSARY FORMULATION OF NIGELLA SATIVA, ON PREGNANT RATS (SHORT COMMUNICATION). AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(1), 117-123. SID. https://sid.ir/paper/326314/en

    Vancouver: Copy

    SALARINIA REZA, RAKHSHANDEH HASSAN, OLIAEE DAVOOD, GUL GHASEMI SIMA, GHORBANI AHMAD. SAFETY EVALUATION OF PHYTOVAGEX, A PESSARY FORMULATION OF NIGELLA SATIVA, ON PREGNANT RATS (SHORT COMMUNICATION). AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(1):117-123. Available from: https://sid.ir/paper/326314/en

    IEEE: Copy

    REZA SALARINIA, HASSAN RAKHSHANDEH, DAVOOD OLIAEE, SIMA GUL GHASEMI, and AHMAD GHORBANI, “SAFETY EVALUATION OF PHYTOVAGEX, A PESSARY FORMULATION OF NIGELLA SATIVA, ON PREGNANT RATS (SHORT COMMUNICATION),” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 1, pp. 117–123, 2016, [Online]. Available: https://sid.ir/paper/326314/en

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