THE PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST LIVER INJURY: A REVIEW

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MOLLAZADEH HAMID; HOSSEINZADEH HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2014 | Volume:17 | Issue:12 Page(s): 958-966

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Information Journal Paper

Title

THE PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST LIVER INJURY: A REVIEW

Author(s)

MOLLAZADEH HAMID | HOSSEINZADEH HOSSEIN | Issue Writer Certificate

Keywords

BLACK CUMIN

HEPATITIS

LIVER INJURY

NIGELLA SATIVA

THYMOQUINONE

Abstract

Nigella sativa (Family Ranunculaceae) is a widely used medicinal plant throughout the world. N. sativa is referred in the Middle East as a part of an overall holistic approach to health. Pharmacological properties of N. sativa including immune stimulant, hypotensive, anti-inflammatory, anti-cancer, antioxidant, hypoglycemic, spasmolytic and bronchodilator have been shown. Reactive oxygen species (ROS) and oxidative stress are known as the major causes of many diseases such as LIVER INJURY and many substances and drugs can induce oxidative damage by generation of ROS in the body. Many pharmacological properties of N. sativa are known to be attributed to the presence of THYMOQUINONE and its antioxidant effects. THYMOQUINONE protects liver from injury via different mechanisms including inhibition of iron-dependent lipid peroxidation, elevation in total thiol content and glutathione level, radical scavengering, increasing the activity of quinone reductase, catalase, superoxide dismutase and glutathione transferase, inhibition of NF-kB activity and inhibition of both cyclooxygenase and lipoxygenase. Therefore, this review aimed to highlight the roles of ROS in liver diseases and the mechanisms of N. sativa in prevention of LIVER INJURY.

Cites

SAFETY EVALUATION OF PHYTOVAGEX, A PESSARY FORMULATION OF NIGELLA SATIVA, ON PREGNANT RATS (SHORT COMMUNICATION)

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APA: Copy

MOLLAZADEH, HAMID, & HOSSEINZADEH, HOSSEIN. (2014). THE PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST LIVER INJURY: A REVIEW. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(12), 958-966. SID. https://sid.ir/paper/638763/en

Vancouver: Copy

MOLLAZADEH HAMID, HOSSEINZADEH HOSSEIN. THE PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST LIVER INJURY: A REVIEW. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2014;17(12):958-966. Available from: https://sid.ir/paper/638763/en

IEEE: Copy

HAMID MOLLAZADEH, and HOSSEIN HOSSEINZADEH, “THE PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST LIVER INJURY: A REVIEW,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 17, no. 12, pp. 958–966, 2014, [Online]. Available: https://sid.ir/paper/638763/en

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