مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ADRIAMYCIN-INDUCED OXIDATIVE STRESS IS PREVENTED BY MIXED HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA IN RAT KIDNEY

Pages

  86-94

Abstract

 Objective: Inflammation and OXIDATIVE STRESS is considered to have a crucial role in induction of nephropathy. CURCUMA LONGA (C. longa) and NIGELLA SATIVA (N. sativa) have anti-inflammatory and antioxidant effects. This study was designed to investigate the effect of mixed hydro-alcoholic extract of N.sativa and C. longa on the OXIDATIVE STRESS induced by ADRIAMYCIN (ADR) in rat kidney.Materials and Methods: The animals were divided into 6 groups: control (CO), ADR, ADRIAMYCIN+Vitamin C (ADR+VIT C), C. longa extract+ADRIAMYCIN (C.LE+ADR), N. sativa extract+ADRIAMYCIN (N.SE+ADR) and C. longa extract+N. sativa extract+ADRIAMYCIN (N.S+C.L+ADR). ADR (5mg/kg) was injected intravenously, whereas VITC (100mg/kg) and extract of C. longa (1000mg/kg) and N. sativa (200mg/kg) were administrated orally. Finally, the renal tissue, urine and blood samples were collected and submitted to measure of redox markers, osmolarity and renal index.Results: The renal content of total thiol and superoxide dismutase (SOD) activity significantly decreased and Malondialdehyde (MDA) concentration increased in ADRIAMYCIN group compared to control group. The renal content of total thiol and SOD activity significantly enhanced and MDA concentration reduced in treated-mixed extract of C. longa and N. sativa along with ADR group compared to ADR group. The mixed extract did not restore increased renal index percentage induced by ADR. There also was no significant difference in urine and serum osmolarity between the groups.Conclusion: hydro-alcoholic extracts of N.sativa and C.longa led to an improvement in ADR-induced OXIDATIVE STRESS and mixed administration of the extracts enhanced the aforementioned therapeutic effect.

Cites

References

Cite

APA: Copy

MOHEBBATI, REZA, SHAFEI, MOHAMMAD NASER, SOUKHTANLOO, MOHAMMAD, MOHAMMADIAN ROSHAN, NOEMA, KHAJAVI RAD, ABOLFAZL, ANAEIGOUDARI, AKBAR, HOSSEINIAN, SARA, KARIMI, SAREH, & BEHESHTI, FARIMAH. (2016). ADRIAMYCIN-INDUCED OXIDATIVE STRESS IS PREVENTED BY MIXED HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA IN RAT KIDNEY. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(1), 86-94. SID. https://sid.ir/paper/326317/en

Vancouver: Copy

MOHEBBATI REZA, SHAFEI MOHAMMAD NASER, SOUKHTANLOO MOHAMMAD, MOHAMMADIAN ROSHAN NOEMA, KHAJAVI RAD ABOLFAZL, ANAEIGOUDARI AKBAR, HOSSEINIAN SARA, KARIMI SAREH, BEHESHTI FARIMAH. ADRIAMYCIN-INDUCED OXIDATIVE STRESS IS PREVENTED BY MIXED HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA IN RAT KIDNEY. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(1):86-94. Available from: https://sid.ir/paper/326317/en

IEEE: Copy

REZA MOHEBBATI, MOHAMMAD NASER SHAFEI, MOHAMMAD SOUKHTANLOO, NOEMA MOHAMMADIAN ROSHAN, ABOLFAZL KHAJAVI RAD, AKBAR ANAEIGOUDARI, SARA HOSSEINIAN, SAREH KARIMI, and FARIMAH BEHESHTI, “ADRIAMYCIN-INDUCED OXIDATIVE STRESS IS PREVENTED BY MIXED HYDRO-ALCOHOLIC EXTRACT OF NIGELLA SATIVA AND CURCUMA LONGA IN RAT KIDNEY,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 1, pp. 86–94, 2016, [Online]. Available: https://sid.ir/paper/326317/en

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