HEPATOPROTECTIVE EFFECT OF ROSA CANINA FRUIT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SADEGHI HEIBATOLLAH; HOSSEINZADEH SALEH; AKBARTABAR TOURI MEHDI; GHAVAMZADEH MEHDI; JAFARI BARMAK MEHRZAD; SAYAHI MOSLEM; SADEGHI HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2016 | Volume:6 | Issue:2 Page(s): 181-188

Download Full-Text

View:

301

Download:

125

Cites:

Information Journal Paper

Title

HEPATOPROTECTIVE EFFECT OF ROSA CANINA FRUIT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT

Author(s)

Keywords

HEPATOPROTECTIVE

TETRACHLORIDE

ROSA CANINA FRUIT

RATS

Abstract

Objective: The present study was conducted to investigate the HEPATOPROTECTIVE activity of hydro-ethanolic fruit extract of Rosa canina (R. canina) against carbon TETRACHLORIDE (CCl4)-induced hepatotoxicity in RATS.Materials and Methods: Male Wistar albino RATS were randomly divided into six groups of 8 animals of each, including control, toxic (CCl4), R. canina 250, 500, and 750 mg/kg + CCl4 and R. canina 750 mg/kg alone. R. canina (p.o., daily) and CCl4 (1 ml/kg twice a week, 50% v/v in olive oil, i.p.) were administered to animals for six weeks. Serum analysis was performed to assay the levels of aspartate aminotransferase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP), albumin (ALB), total protein (TP) and malondialdehyde (MDA). Biochemical observations were also supplemented with histopathological examination (haematoxylin and eosin staining) of liver section.Results: Hepatotoxicity was evidenced by considerable increase in serum levels of AST, ALT, ALP, and lipid peroxidation (MDA) and decrease in levels of ALB and TP. Injection of CCL4 also induced congestion in central vein, and lymphocyte infiltration. Treatment with hydro-alcoholic fruit extract of R. canina at doses of 500 and 750 mg/kg significantly reduced CCl4-elevated levels of ALT, AST, ALP and MDA (p<0.01). The extract also increased the serum levels of ALB and TP compared to CCl4 group (p<0.01) at the indicated dose Histopathological studies supported the biochemical finding.Conclusion: Our finding indicated HEPATOPROTECTIVE effects of the hydro-alcoholic fruit extract of R. canina on CCl4-induced hepatic damage in RATS and suggested that these effects may be produced through reducing oxidative stress.

Cites

No record.

References

Cite

APA: Copy

SADEGHI, HEIBATOLLAH, HOSSEINZADEH, SALEH, AKBARTABAR TOURI, MEHDI, GHAVAMZADEH, MEHDI, JAFARI BARMAK, MEHRZAD, SAYAHI, MOSLEM, & SADEGHI, HOSSEIN. (2016). HEPATOPROTECTIVE EFFECT OF ROSA CANINA FRUIT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(2), 181-188. SID. https://sid.ir/paper/326336/en

Vancouver: Copy

SADEGHI HEIBATOLLAH, HOSSEINZADEH SALEH, AKBARTABAR TOURI MEHDI, GHAVAMZADEH MEHDI, JAFARI BARMAK MEHRZAD, SAYAHI MOSLEM, SADEGHI HOSSEIN. HEPATOPROTECTIVE EFFECT OF ROSA CANINA FRUIT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(2):181-188. Available from: https://sid.ir/paper/326336/en

IEEE: Copy

HEIBATOLLAH SADEGHI, SALEH HOSSEINZADEH, MEHDI AKBARTABAR TOURI, MEHDI GHAVAMZADEH, MEHRZAD JAFARI BARMAK, MOSLEM SAYAHI, and HOSSEIN SADEGHI, “HEPATOPROTECTIVE EFFECT OF ROSA CANINA FRUIT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RAT,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 2, pp. 181–188, 2016, [Online]. Available: https://sid.ir/paper/326336/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops