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Information Journal Paper

Title

EFFECTS OF BERBERINE ON ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE

Pages

  198-204

Abstract

 Objective: It has been shown that BERBERINE, a major component of BERBERIS VULGARIS extract, modulates the activity of several neurotransmitter systems including dopamine (Da) and N-methyl-D-aspartate (NMDA) contributing to rewarding and reinforcing effects of MORPHINE. Drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. In the present study, we investigated the alleviating effects of BERBERINE on the acquisition and reinstatement of MORPHINE-induced CONDITIONED PLACE PREFERENCE (CPP) in mice.Materials and Methods: In male NMRI mice, the acquisition of CPP was established by 40 mg/kg of MORPHINE sulphate injection and extinguished after the extinction training and reinstated by a 10 mg/kg injection of MORPHINE. The effects of different doses of BERBERINE (5, 10, and 20 mg/kg) on the acquisition and reinstatement induced by MORPHINE were evaluated in a CONDITIONED PLACE PREFERENCE test.Results: The results showed that intraperitoneal administration of BERBERINE (5, 10, and 20 mg/kg) did not induce conditioned appetitive or aversive effects. Injection of BERBERINE (10 and 20 mg/kg) 2 h before the MORPHINE administration reduced acquisition of MORPHINE-induced CPP. In addition, same doses of BERBERINE significantly prevented the reinstatement of MORPHINE-induced CPP.Conclusion: These results suggest that BERBERINE can reduce the acquisition and reinstatement of MORPHINE-induced CONDITIONED PLACE PREFERENCE and may be useful in treatment of MORPHINE addiction.

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    APA: Copy

    VAHDATI HASSANI, FAEZEH, HASHEMZAEI, MAHMOUD, AKBARI, EDRIS, IMENSHAHIDI, MOHSEN, & HOSSEINZADEH, HOSSEIN. (2016). EFFECTS OF BERBERINE ON ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(2), 198-204. SID. https://sid.ir/paper/326344/en

    Vancouver: Copy

    VAHDATI HASSANI FAEZEH, HASHEMZAEI MAHMOUD, AKBARI EDRIS, IMENSHAHIDI MOHSEN, HOSSEINZADEH HOSSEIN. EFFECTS OF BERBERINE ON ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(2):198-204. Available from: https://sid.ir/paper/326344/en

    IEEE: Copy

    FAEZEH VAHDATI HASSANI, MAHMOUD HASHEMZAEI, EDRIS AKBARI, MOHSEN IMENSHAHIDI, and HOSSEIN HOSSEINZADEH, “EFFECTS OF BERBERINE ON ACQUISITION AND REINSTATEMENT OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MICE,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 2, pp. 198–204, 2016, [Online]. Available: https://sid.ir/paper/326344/en

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