ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF ZIZIPHUS JUJUBE ON CERVICAL AND BREAST CANCER CELLS (SHORT COMMUNICATION)

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ABEDINI MOHAMMAD REZA; ERFANIAN NAFISEH; NAZEM HABIBOLLAH; JAMALI SARA; HOSHYAR REYHANE

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Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2016 | Volume:6 | Issue:2 Page(s): 142-148

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Information Journal Paper

Title

ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF ZIZIPHUS JUJUBE ON CERVICAL AND BREAST CANCER CELLS (SHORT COMMUNICATION)

Author(s)

Keywords

ZIZIPHUS JUJUBE

CERVICAL CANCER

BREAST CANCER

APOPTOSIS

Abstract

Objective: ZIZIPHUS JUJUBE (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and BREAST CANCER cells in vitro.Materials and Methods: The cervical OV2008 and breast MCF-7 cancer cells were incubated with different concentrations of Jujube aqueous extraction (0-3 mg/ml) for various times (0-72 h). Cell viability was assessed by Trypan Blue and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The expression of two APOPTOSIS-related genes in treated cells evaluated by quantitative Real Time -PCR analysis.Results: Jujube significantly inhibited cancer cell viability in a dose- and time- dependent manner. Herb-induced APOPTOSIS was associated with enhanced expression of Bax and decreased Bcl2 gene leading eventually to a time-dependent six fold increase in the Bax/Bcl-2 ratio.Conclusion: These results indicated that Jujube may be a natural potential and promising agent to prevent or treat human cancers.

Cites

The effect of endurance training and Ziziphus jujube extract consumption on apoptosis of cardiac tissue in male Wistar rats

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APA: Copy

ABEDINI, MOHAMMAD REZA, ERFANIAN, NAFISEH, NAZEM, HABIBOLLAH, JAMALI, SARA, & HOSHYAR, REYHANE. (2016). ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF ZIZIPHUS JUJUBE ON CERVICAL AND BREAST CANCER CELLS (SHORT COMMUNICATION). AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 6(2), 142-148. SID. https://sid.ir/paper/326345/en

Vancouver: Copy

ABEDINI MOHAMMAD REZA, ERFANIAN NAFISEH, NAZEM HABIBOLLAH, JAMALI SARA, HOSHYAR REYHANE. ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF ZIZIPHUS JUJUBE ON CERVICAL AND BREAST CANCER CELLS (SHORT COMMUNICATION). AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2016;6(2):142-148. Available from: https://sid.ir/paper/326345/en

IEEE: Copy

MOHAMMAD REZA ABEDINI, NAFISEH ERFANIAN, HABIBOLLAH NAZEM, SARA JAMALI, and REYHANE HOSHYAR, “ANTI-PROLIFERATIVE AND APOPTOTIC EFFECTS OF ZIZIPHUS JUJUBE ON CERVICAL AND BREAST CANCER CELLS (SHORT COMMUNICATION),” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 6, no. 2, pp. 142–148, 2016, [Online]. Available: https://sid.ir/paper/326345/en

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