مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECT OF EXTRACTS OF MARRUBIUM ASTRACANICUM JACQ. AERIAL PARTS

Pages

  73-79

Abstract

 Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. MARRUBIUM ASTRACANICUM Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant ANALGESIC activity in acute phase (0-5 min after formalin injection) of formalin test (p<0.05 as compared to control and p>0.05 in comparison with morphine). In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant ANALGESIC activity (p<0.001 as compared to control and p>0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.

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    APA: Copy

    KAHKESHANI, NILOOFAR, GHAREDAGHI, MILAD, HADJIAKHOONDI, ABBAS, SHARIFZADEH, MOHAMMAD, & KHANAVI, MAHNAZ. (2017). ANTINOCICEPTIVE EFFECT OF EXTRACTS OF MARRUBIUM ASTRACANICUM JACQ. AERIAL PARTS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 7(1), 73-79. SID. https://sid.ir/paper/326362/en

    Vancouver: Copy

    KAHKESHANI NILOOFAR, GHAREDAGHI MILAD, HADJIAKHOONDI ABBAS, SHARIFZADEH MOHAMMAD, KHANAVI MAHNAZ. ANTINOCICEPTIVE EFFECT OF EXTRACTS OF MARRUBIUM ASTRACANICUM JACQ. AERIAL PARTS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2017;7(1):73-79. Available from: https://sid.ir/paper/326362/en

    IEEE: Copy

    NILOOFAR KAHKESHANI, MILAD GHAREDAGHI, ABBAS HADJIAKHOONDI, MOHAMMAD SHARIFZADEH, and MAHNAZ KHANAVI, “ANTINOCICEPTIVE EFFECT OF EXTRACTS OF MARRUBIUM ASTRACANICUM JACQ. AERIAL PARTS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 7, no. 1, pp. 73–79, 2017, [Online]. Available: https://sid.ir/paper/326362/en

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