In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates

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FAZLY BAZZAZ BIBI SEDIGHEH; KHAMENEH BAHMAN; Zahedian Ostad Mohammad Reza; HOSSEINZADEH HOSSEIN

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Journal: Avicenna Journal of Phytomedicine Year:2018 | Volume:8 | Issue:3 Page(s): 246-253

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Title

In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates

Author(s)

FAZLY BAZZAZ BIBI SEDIGHEH | KHAMENEH BAHMAN | Zahedian Ostad Mohammad Reza | HOSSEINZADEH HOSSEIN | Issue Writer Certificate

Keywords

Antibiotics

Combination therapy

Methylxanthines

Herbal extract

Natural compounds

Resistant pathogens

Abstract

In recent years, there has been an increasing interest in using herbal products to overcome bacterial resistance. The aim of this study was to investigate the effect of lemon verbena aqueous extract, verbascoside and caffeine in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus and Escherichia coli strains. Materials and Methods: The MIC and MBC values of different antibacterial agents against bacterial strains were determined. The effect of co-administration lemon verbena extract, verbascoside, and caffeine and gentamicin was studied in vitro using a checkerboard method and calculating fraction inhibitory concentration index (FICI). Results: Herbal extract, verbascoside and caffeine alone showed no inhibitory effects on any of the bacterial strains (at doses up to 200  g/ml). Herbal extract, verbascoside and caffeine were able to decrease the MIC of gentamicin against the standard resistant strains and two clinical isolates. Among these combinations, the co-administration of verbascoside and gentamicin was more effective and synergistic activities (FICI<1) against clinical isolates were observed. Conclusion: The results of the present study revealed that Herbal extract, verbascoside and caffeine potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and E. coli.

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APA: Copy

FAZLY BAZZAZ, BIBI SEDIGHEH, KHAMENEH, BAHMAN, Zahedian Ostad, Mohammad Reza, & HOSSEINZADEH, HOSSEIN. (2018). In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(3), 246-253. SID. https://sid.ir/paper/326412/en

Vancouver: Copy

FAZLY BAZZAZ BIBI SEDIGHEH, KHAMENEH BAHMAN, Zahedian Ostad Mohammad Reza, HOSSEINZADEH HOSSEIN. In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(3):246-253. Available from: https://sid.ir/paper/326412/en

IEEE: Copy

BIBI SEDIGHEH FAZLY BAZZAZ, BAHMAN KHAMENEH, Mohammad Reza Zahedian Ostad, and HOSSEIN HOSSEINZADEH, “In vitro evaluation of antibacterial activity of verbascoside, lemon verbena extract and caffeine in combination with gentamicin against drug-resistant Staphylococcus aureus and Escherichia coli clinical isolates,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 3, pp. 246–253, 2018, [Online]. Available: https://sid.ir/paper/326412/en

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