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1

Information Journal Paper

Title

A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism

Pages

  161-169

Abstract

 Objective: The present study was performed to evaluate the effects of hydro-alcoholic extract of Portulaca oleracea (P. oleracea) seeds and Vitamin C on biochemical and hemodynamic parameters in cardiac tissue of Rats with Subclinical hyperthyroidism. Materials and Methods: Forty eight male Rats were divided into six groups of 8 and treated for 4 weeks. T4 group received daily injection of levothyroxine sodium (20 μ g/kg) and control group was given daily injection of saline. T4-Po groups were given T4 plus 100, 200, and 400 mg/kg of P. oleracea seeds extract in drinking water daily. T4-Vit C group received T4 plus daily injection of Vitamin C (100 mg/kg). At the end of the experiment, body weight, serum free T4 level, left ventricular developed pressure (LVDP), malondialdehyde (MDA) and total thiol levels were measured. Results: Free T4 levels were increased in all groups that were treated with T4. Weight gain was decreased in T4 and T4-Po100 groups compared to control group (p<0. 001 and p<0. 05). However, body weight was increased in T4-Po (200 and 400) and T4-Vit C groups compared to T4 group. LVDP was increased in T4 group compared to control group but, LVDP was decreased in T4-Po and T4-Vit C groups. Malondialdehyde was decreased in T4-Po groups and T4-Vit C group compared to T4 group. Total thiol groups were increased in T4-Po (200 and 400) and T4-Vit C groups compared to T4 group. Conclusion: The results showed that P. oleracea extract has a protective effect on cardiac dysfunction due to Subclinical hyperthyroidism induced by levothyroxine sodium in Rats.

Cites

References

Cite

APA: Copy

Khodadadi, Hadi, PAKDEL, ROGHAYEH, KHAZAEI, MAJID, Niazmand, Said, Bavarsad, Kowsar, & HADJZADEH, MOUSA AL REZA. (2018). A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(2), 161-169. SID. https://sid.ir/paper/326454/en

Vancouver: Copy

Khodadadi Hadi, PAKDEL ROGHAYEH, KHAZAEI MAJID, Niazmand Said, Bavarsad Kowsar, HADJZADEH MOUSA AL REZA. A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(2):161-169. Available from: https://sid.ir/paper/326454/en

IEEE: Copy

Hadi Khodadadi, ROGHAYEH PAKDEL, MAJID KHAZAEI, Said Niazmand, Kowsar Bavarsad, and MOUSA AL REZA HADJZADEH, “A comparison of the effects of Portulaca oleracea seeds hydro-alcoholic extract and Vitamin C on biochemical, hemodynamic and functional parameters in cardiac tissue of rats with subclinical hyperthyroidism,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 2, pp. 161–169, 2018, [Online]. Available: https://sid.ir/paper/326454/en

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