Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats

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Amadike Ugbogu Eziuche; Chibueze Ude Victor; Elekwa Iheanyichukwu; Arunsi Uche Okuu; Uche Ikonne Chikezie; Nwakanma Chinedu

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Journal: Avicenna Journal of Phytomedicine Year:2018 | Volume:8 | Issue:6 Page(s): 478-487

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Title

Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats

Author(s)

Keywords

Musa Paradisiaca

acute toxicity

Sub-acute toxicity

Haematology

Lipid profile

Histopathology

Abstract

This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa Paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for behavioral changes, toxicity signs and mortality. In sub-acute test, the rats were orally administered with fermented M. paradisiaca extract (200, 400 and 800 mg/kg/day) for 14 days. Haematological and serum biochemical parameters were evaluated and histopathological studies of the liver and kidney were done. The study was performed from June to July 2017. Results: Concerning the acute toxicity, no toxicity signs or death were recorded and an LD50 value of >5 g/kg for fermented extract of M. paradisiaca was observed. Regarding the Sub-acute toxicity, ingestion of the fermented extract of M. paradisiaca caused no significant effects (p<0. 05) in terms of relative organ weight, body weight percentage, haemoglobin, red blood cells count, electrolytes levels, lymphocytes count, basophils count, and aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. However, significant differences (p<0. 05) were observed in white blood cells, eosinophils, platelets, neutrophils and monocytes counts, and urea, creatinine, alanine aminotransferase (ALT) and high-density lipoprotein (HDL) levels. The histological assessments of the liver and kidney showed normal results. Conclusion: The findings of this study has suggested that daily administration of fermented extract of M. paradisiaca at doses up to 800 mg/kg for 14 days, is not toxic and may be considered safe for therapeutic uses.

Cites

Evaluating bioactive constituents and toxicological effects of aqueous extract of fermented Pentaclethra macrophylla seeds in rats

References

HYPNOTIC EFFECT OF OCIMUM BASILICUM ON PENTOBARBITAL-INDUCED SLEEP IN MICE

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APA: Copy

Amadike Ugbogu, Eziuche, Chibueze Ude, Victor, Elekwa, Iheanyichukwu, Arunsi, Uche Okuu, Uche Ikonne, Chikezie, & Nwakanma, Chinedu. (2018). Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(6), 478-487. SID. https://sid.ir/paper/326468/en

Vancouver: Copy

Amadike Ugbogu Eziuche, Chibueze Ude Victor, Elekwa Iheanyichukwu, Arunsi Uche Okuu, Uche Ikonne Chikezie, Nwakanma Chinedu. Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(6):478-487. Available from: https://sid.ir/paper/326468/en

IEEE: Copy

Eziuche Amadike Ugbogu, Victor Chibueze Ude, Iheanyichukwu Elekwa, Uche Okuu Arunsi, Chikezie Uche Ikonne, and Chinedu Nwakanma, “Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 6, pp. 478–487, 2018, [Online]. Available: https://sid.ir/paper/326468/en

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