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Information Journal Paper

Title

Carob (Ceratonia siliqua L. ) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of Nrf2 and iNOS

Pages

  35-49

Abstract

 Objective: Carob (Ceratonia siliqua L. ) is an evergreen tree with fruits that have potent antioxidant activity. The aim of this study was to investigate alleviative effects of carob fruit hydro-alcoholic extract (CFHAE) against reproductive toxicity induced by lead (Pb) in male mice. Materials and Methods: Forty-two NMRI adult male mice were randomly categorized into 7 groups (N=6). Group I was the control group and received no treatment. Group II was the sham group and received 0. 2 ml distilled water per day. Group III (Pb group) received Pb acetate 1000 ppm/kg/day. Groups IV and V received CFHAE 500 and 1000 mg/kg/day, respectively. Groups VI and VII received both Pb 1000 ppm/kg/day and CFHAE at doses of 500 and 1000 mg/kg/day, respectively at the same time. The groups were treated by gavage. After 35 days, sperm parameters (count, motility, morphology, viability, DNA damage, and teratozoospermia index), total antioxidant capacity (TAC), reduced glutathione content (GSH), antioxidant enzymes (SOD, CAT, and GPx) activity, MDA levels, and sex hormones (FSH, LH, and testosterone) concentrations in serum, testicular expression of Nrf2 and iNOS genes and histopathological alterations were evaluated. Results: Our findings revealed that co-administration of CFHAE with Pb significantly (p<0. 05 to p<0. 01) improved sperm parameters, elevated sex hormones, TAC, GSH content, and antioxidant enzymes activity of serum, decreased serum MDA levels, and down-regulated testicular expression of Nrf2 and iNOS genes compared with Pb group. Also, CFHAE ameliorated histopathological alterations in testis tissue caused by Pb. Conclusion: CFHAE can alleviate reproductive toxicity following Pb exposure in male mice.

Cites

References

Cite

APA: Copy

SOLEIMANZADEH, ALI, Kian, Mehdi, MORADI, SAJJAD, & MAHMOUDI, SORAYA. (2020). Carob (Ceratonia siliqua L. ) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of Nrf2 and iNOS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(1), 35-49. SID. https://sid.ir/paper/326474/en

Vancouver: Copy

SOLEIMANZADEH ALI, Kian Mehdi, MORADI SAJJAD, MAHMOUDI SORAYA. Carob (Ceratonia siliqua L. ) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of Nrf2 and iNOS. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(1):35-49. Available from: https://sid.ir/paper/326474/en

IEEE: Copy

ALI SOLEIMANZADEH, Mehdi Kian, SAJJAD MORADI, and SORAYA MAHMOUDI, “Carob (Ceratonia siliqua L. ) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of Nrf2 and iNOS,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 1, pp. 35–49, 2020, [Online]. Available: https://sid.ir/paper/326474/en

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