Short Communication: The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial

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DASTANI MOSTAFA; BIGDELU LEILA; Hoseinzadeh Mahsa; RAHIMI HAMID REZA; Karimani Asieh; MOHAMMADPOUR AMIR HOOSHANG; SALARI MASOUMEH

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Journal: Avicenna Journal of Phytomedicine Year:2019 | Volume:9 | Issue:1 Page(s): 1-9

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Title

Short Communication: The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial

Author(s)

Keywords

Angina

Unstable

Arrhythmias

Cardiac

Curcumin

Heart failure

Acute coronary syndrome

Abstract

Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of Unstable Angina which leads to acute myocardial infarction, Arrhythmias and eventually Heart failure. Curcumin has anti inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of Curcumin on the prevention of atrial and ventricular Arrhythmias and Heart failure in patients with Unstable Angina. Materials and Methods: Forty patients with Unstable Angina who met the trial inclusion and exclusion criteria, participated in this double-blind randomized clinical trial. The patients were randomized into two groups: Curcumin (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular Arrhythmias were recorded by Holter monitors in cardiology ward, Ghaem academic hospital, Mashhad, Iran. Progression to Heart failure, myocardial infarction, and pulmonary and cardiopulmonary resuscitation events as well as mortality were recorded daily throughout the study. Results: There were no significant differences between the two groups in atrial and ventricular Arrhythmias (p=0. 2), and other echocardiographic parameters (Ejection fraction, E, A, E/A ratio, Em, and pulmonary artery pressure) at baseline and five days after the start of the trial. Conclusion: NanoCurcumin administered at the dose of 80 mg/day for five days had no effect in the incidence of cardiovascular complications in patients with Unstable Angina.

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References

Safety and efficacy of nanocurcumin as addon therapy to riluzole in patients with amyotrophic lateral sclerosis: A pilot randomized clinical trial

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APA: Copy

DASTANI, MOSTAFA, BIGDELU, LEILA, Hoseinzadeh, Mahsa, RAHIMI, HAMID REZA, Karimani, Asieh, MOHAMMADPOUR, AMIR HOOSHANG, & SALARI, MASOUMEH. (2019). Short Communication: The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(1), 1-9. SID. https://sid.ir/paper/326492/en

Vancouver: Copy

DASTANI MOSTAFA, BIGDELU LEILA, Hoseinzadeh Mahsa, RAHIMI HAMID REZA, Karimani Asieh, MOHAMMADPOUR AMIR HOOSHANG, SALARI MASOUMEH. Short Communication: The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(1):1-9. Available from: https://sid.ir/paper/326492/en

IEEE: Copy

MOSTAFA DASTANI, LEILA BIGDELU, Mahsa Hoseinzadeh, HAMID REZA RAHIMI, Asieh Karimani, AMIR HOOSHANG MOHAMMADPOUR, and MASOUMEH SALARI, “Short Communication: The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 1, pp. 1–9, 2019, [Online]. Available: https://sid.ir/paper/326492/en

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