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Title

Effects of Clinacanthus nutans leaf extract on lipopolysaccharide induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study

Pages

  164-186

Abstract

 Objective: This research revealed the biochemical outcomes of metabolic dysregulation in serum associated with physiological sickness Behavior following lipopolysaccharide (LPS)-induced Neuroinflammation in rats, and treatment with Clinacanthus nutans (CN). Verification of H NMR analysis of the CN aqueous extract proved the existence of bioactive phytochemical constituents’ in extract. Materials and Methods: Twenty-five rats were subjected to unilateral stereotaxic injection of 10 µ L LPS (1 mg/mL), while another ten rats were injected with phosphate-buffered saline (PBS, 10 µ L) as control. Then, 29 parameters of rat Behavior related to sickness were tracked by a device software (SMART 3. 0. 1) on days 0 and 14 of CN treatment. The acquired and accumulated data were analyzed using multivariate data analysis with the SIMCA Software package (version 13, Umetrics AB; Umeå , Sweden). The pattern trends of related groups were documented using PCA and OPLS analysis. Results: A similar ameliorated correlation pattern was detected between improvement in physiological sickness Behavior and antiinflammatory biomarkers by the 1 H NMR spectra of the sera following treatment with CN (500 and 1000 mg/kg body weight (bw)) and the control drug (dextromethorphan hydrobromide, 5 mg/kg of rats bw) in rats. Here, 21 biomarkers were detected for Neuroinflammation. Treatment with the aqueous CN extract resulted in a statistically significant alteration in Neuroinflammation metabolite biomarkers, including ethanol, choline, and acetate. Conclusion: This result denotes that the Metabolomics approach is a reliable tool to disclose the relationship between central Neuroinflammation, and systemic metabolic and physiological disturbances which could be used for future ethno-pharmacological assessments.

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    APA: Copy

    Azam, Amalina Ahmad, Ismail, Intan Safinar, Shaikh, Mohd Farooq, Shaari, Khozirah, & Abas, Faridah. (2019). Effects of Clinacanthus nutans leaf extract on lipopolysaccharide induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(2), 164-186. SID. https://sid.ir/paper/326505/en

    Vancouver: Copy

    Azam Amalina Ahmad, Ismail Intan Safinar, Shaikh Mohd Farooq, Shaari Khozirah, Abas Faridah. Effects of Clinacanthus nutans leaf extract on lipopolysaccharide induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(2):164-186. Available from: https://sid.ir/paper/326505/en

    IEEE: Copy

    Amalina Ahmad Azam, Intan Safinar Ismail, Mohd Farooq Shaikh, Khozirah Shaari, and Faridah Abas, “Effects of Clinacanthus nutans leaf extract on lipopolysaccharide induced neuroinflammation in rats: A behavioral and H NMR-based metabolomics study,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 2, pp. 164–186, 2019, [Online]. Available: https://sid.ir/paper/326505/en

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