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Information Journal Paper

Title

Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus

Pages

  221-236

Abstract

 Objective: Acanthus syriacus (AS) is one of the valuable herbal plants with immunomodulatory potentials. The aim of this study is to assemble a phytochemical investigation of A. syriacus exploring its Anti-inflammatory and antinociceptive properties, identification of its most active compound(s) and elucidating their structure and determining their mechanisms of action. Materials and Methods: Bio-guided fractionation and isolationschemes were used utilizing RP-HPLC, CC, C-NMR, and biological-models were used to evaluate their effects against inflammation and neuropathic-pain (NP). Results: The outcomes showed that the most active fraction (FKCA) of AS was identified. Two of the three components of FKCA were identified by chromatographic-methods, while the third compound was isolated, its structure was elucidated and its was named Kromeic acid (KRA); FKCA contained Ferulic acid (27. 5%), Kromeic acid (48. 1%), and chlorogenic acid (24. 4%). AS, FKCA and KRA showed significant (p˂ 0. 05) Anti-inflammatory and antinociceptive potentials in the management of allodynia and thermal-hyperalgesia in NP. AS and FCKA showed comparatively equipotent antinociceptive-effects. FKCA showed higher Antinociceptive effects than KRA suggesting additive-effects among FKCA components. The Anti-inflammatory, insulin secretagogue, oxidative-stress reducing, and protective effects against NO-induced neuronal-toxicity might be amongst the possible mechanisms of tested compounds to alleviate NP. Conclusion: Here, we report the isolation and structure elucidation of a novel quinic-acid derivative, KRA. A. syriacus, FKCA, and KRA might be used as a novel complementary approach to ameliorate a variety of painful-syndromes.

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    APA: Copy

    Raafat, Karim M.. (2019). Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(3), 221-236. SID. https://sid.ir/paper/326511/en

    Vancouver: Copy

    Raafat Karim M.. Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(3):221-236. Available from: https://sid.ir/paper/326511/en

    IEEE: Copy

    Karim M. Raafat, “Anti-inflammatory and anti-neuropathic effects of a novel quinic acid derivative from Acanthus syriacus,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 3, pp. 221–236, 2019, [Online]. Available: https://sid.ir/paper/326511/en

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