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Information Journal Paper

Title

Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis

Pages

  374-385

Abstract

 Objective: The glucose-reducing effects of Troxerutin was previously proven. This study was conducted to evaluate Troxerutin effect on testicular structure and spermatozoid parameters in type-1 diabetic adult male Rats. Materials and Methods: Fifty male Wistar Rats were randomly classified into 5 groups as follows: control (C), Troxerutin (T), diabetic (DM), Troxerutin-treated DM (DT) and insulin-treated DM (DI). Testicular structure, apoptosis, lipid peroxidation and antioxidant activity, and spermatozoid parameters were assessed 4 weeks after initiation of the interventions. Results: The results revealed that Diabetes caused testicular stereological changes and significantly increased blood glucose level, testicular MDA content and apoptosis but decreased insulin level, testicular GPX activity, and sperm parameters compared to controls (p<0. 001 to p<0. 05). AdministRation of Troxerutin and insulin could significantly reduce blood glucose level and improve testicular MDA content, testicular stereological findings and apoptosis compared to DM group (p<0. 001 to p<0. 05). Conclusion: Taken together, Troxerutin, comparable to insulin, effectively improved DM-induced testicular dysfunction and sperm parameters in diabetic Rats and these effects might be mediated through Troxerutin’ s anti-apoptotic effects.

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    APA: Copy

    Qadiri, Afsaneh, MIRZAEI BAVIL, FARIBA, HAMIDIAN, GHOLAMREZA, Zavvari Oskuye, Zohreh, AHMADI, MAHDI, Oghbaei, Hajar, Mehri, Keivan, VATANKHAH, AMIR MANSOUR, & KEYHANMANESH, RANA. (2019). Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(4), 374-385. SID. https://sid.ir/paper/326524/en

    Vancouver: Copy

    Qadiri Afsaneh, MIRZAEI BAVIL FARIBA, HAMIDIAN GHOLAMREZA, Zavvari Oskuye Zohreh, AHMADI MAHDI, Oghbaei Hajar, Mehri Keivan, VATANKHAH AMIR MANSOUR, KEYHANMANESH RANA. Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(4):374-385. Available from: https://sid.ir/paper/326524/en

    IEEE: Copy

    Afsaneh Qadiri, FARIBA MIRZAEI BAVIL, GHOLAMREZA HAMIDIAN, Zohreh Zavvari Oskuye, MAHDI AHMADI, Hajar Oghbaei, Keivan Mehri, AMIR MANSOUR VATANKHAH, and RANA KEYHANMANESH, “Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 4, pp. 374–385, 2019, [Online]. Available: https://sid.ir/paper/326524/en

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