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Information Journal Paper

Title

Dryopteris filix-mas (L. ) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity

Pages

  396-409

Abstract

 Objective: Dryopteris filix-mas (D. filix-mas) (L. ) Schott, (Dryopteridaceae) is used in traditional medicine, particularly in the Southern parts of Nigeria for the treatment of inflammation, Rheumatoid arthritis, wounds and ulcers. In this study, we evaluated he Anti-inflammatory activity of its ethanolic leaf extract and fractions. Materials and Methods: The ethanolic leaf extract and fractions were screened for Anti-inflammatory properties using egg-albuminnduced paw edema, xylene-induced topical ear edema, formaldehyde-induced arthritis and ulcerogenic models. The ethyl acetate most promising vacuum liquid chromatography fraction (VLC-E7) was purified using size exclusion chromatography echnique (Sephadex LH-20) and its structure was elucidated using nuclear magnetic resonance (NMR) and mass spectrometry. Total phenolic and flavonoid contents were also determined. Results: From the study, ethyl acetate and butanol fractions elicited better Anti-inflammatory activities in egg-albumin-induced paw edema, formaldehyde-induced arthritis and xylene-induced topical ear edema. The ethanol extract, ethyl acetate and butanol fractions were Non-ulcerogenic at 200 and 400 mg/kg. The compound solated from Sephadex fraction (SPH-E6) was quercetin-3-O-α-Lrhamnopyranoside. Conclusion: Results of this study justify the ethnomedicinal use of D. filix-mas leaf for treatment of inflammation and Rheumatoid arthritis. We suggest that D. filix-mas could be a prospective Antiinflammatory agent with no gastric irritation side effect, due to its bioactive component, quercetin-3-O-α-L-rhamnopyranoside.

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    APA: Copy

    Erhirhie, Earnest Oghenesuvwe, Emeghebo, Chika Ndubuisi, ILODIGWE, EMMANUEL EMEKA, AJAGHAKU, DANIEL LOTANNA, UMEOKOLI, BLESSING OGECHUKWU, Eze, Peter Maduabuchi, Ngwoke, Kenneth Gerald, & CHIEDU OKOYE, FESTUS BASDEN. (2019). Dryopteris filix-mas (L. ) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(4), 396-409. SID. https://sid.ir/paper/326525/en

    Vancouver: Copy

    Erhirhie Earnest Oghenesuvwe, Emeghebo Chika Ndubuisi, ILODIGWE EMMANUEL EMEKA, AJAGHAKU DANIEL LOTANNA, UMEOKOLI BLESSING OGECHUKWU, Eze Peter Maduabuchi, Ngwoke Kenneth Gerald, CHIEDU OKOYE FESTUS BASDEN. Dryopteris filix-mas (L. ) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(4):396-409. Available from: https://sid.ir/paper/326525/en

    IEEE: Copy

    Earnest Oghenesuvwe Erhirhie, Chika Ndubuisi Emeghebo, EMMANUEL EMEKA ILODIGWE, DANIEL LOTANNA AJAGHAKU, BLESSING OGECHUKWU UMEOKOLI, Peter Maduabuchi Eze, Kenneth Gerald Ngwoke, and FESTUS BASDEN CHIEDU OKOYE, “Dryopteris filix-mas (L. ) Schott ethanolic leaf extract and fractions exhibited profound anti-inflammatory activity,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 4, pp. 396–409, 2019, [Online]. Available: https://sid.ir/paper/326525/en

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