Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IRANSHAHY MILAD; Farhadi Faegheh; Paknejad Babak; ZAREIAN PARVIN; IRANSHAHI MEHRDAD; KARAMI MASOMEH; ABTAHI SEYED REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Phytomedicine Year:2019 | Volume:9 | Issue:5 Page(s): 446-453

Download Full-Text

View:

172

Download:

148

Cites:

Information Journal Paper

Title

Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines

Author(s)

Keywords

Ferula assa-foetida

Apiaceae

Gummosin

Cytotoxicity

MCF-7

PC-3

Abstract

Objective: The present study was conducted to find cytotoxic compounds from oleo-gum-resin of Ferula assa-foetida (asafoetida). Materials and Methods: A dichloromethane extract of asafoetida was subjected to different chromatography analyses (including column chromatography, preparative thin layer chromatography and high performance liquid chromatography) to isolate its bioactive sesquiterpene coumarins. The structures of isolated compounds were elucidated through 1 H-NMR spectra interpretation and comparison with those reported in the literature. To measure the cytotoxic activity of pure compounds, a non-fluorescent substrate called resazurin (alamarBlue ® ) was used in this study. Human breast and prostate cancer cell lines (MCF-7 and PC-3, respectively) and a normal human embryonic stem cell (NIH) were treated with different concentrations (50, 25, 12. 5 and 6. 25 µ g/mL) of pure compounds. Results: In this study, 10 sesquiterpene coumarins were isolated from oleo-gum-resin of F. assa-foetida and cytotoxic activity of 6 compounds was tested against MCF-7 and PC-3 cell lines and NIH cells. Badrakemin acetate (7), ferukrinone (8) and deacetyl kellerin (10) were found for the first time in the oleo-gum-resin of F. assafoetida. Gummosin (4) showed moderate cytotoxic activity with IC50 values of 30 and 32. 1 µ g/mL against PC-3 and MCF-7 cell lines, respectively. None of the isolated compounds showed toxicity against NIH as a normal human cell line. Conclusion: The preferential cytotoxic activity of Gummosin against cancer cell lines is reported for the first time in this study.

Cites

No record.

References

Cite

APA: Copy

IRANSHAHY, MILAD, Farhadi, Faegheh, Paknejad, Babak, ZAREIAN, PARVIN, IRANSHAHI, MEHRDAD, KARAMI, MASOMEH, & ABTAHI, SEYED REZA. (2019). Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(5), 446-453. SID. https://sid.ir/paper/326527/en

Vancouver: Copy

IRANSHAHY MILAD, Farhadi Faegheh, Paknejad Babak, ZAREIAN PARVIN, IRANSHAHI MEHRDAD, KARAMI MASOMEH, ABTAHI SEYED REZA. Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(5):446-453. Available from: https://sid.ir/paper/326527/en

IEEE: Copy

MILAD IRANSHAHY, Faegheh Farhadi, Babak Paknejad, PARVIN ZAREIAN, MEHRDAD IRANSHAHI, MASOMEH KARAMI, and SEYED REZA ABTAHI, “Gummosin, a sesquiterpene coumarin from Ferula assa-foetida is preferentially cytotoxic to human breast and prostate cancer cell lines,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 5, pp. 446–453, 2019, [Online]. Available: https://sid.ir/paper/326527/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops