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Information Journal Paper

Title

Thymol has beneficial effects on the experimental model of ulcerative colitis

Author(s)

 Tahmasebi Pourya | ABTAHI FROUSHANI SEYYED MEYSAM | AFZAL AHANGARAN NAHIDEH | Issue Writer Certificate 

Pages

  538-550

Abstract

 Objective: Thymol, a natural aromatic monoterpene phenol derived from thymus, possesses anti-inflammatory benefits. Here, we evaluated the potential of Thymol therapy in improving an animal model of Ulcerative colitis. Materials and Methods: Luminal instillation of acetic acid was used to induce colitis in male Wistar rats. Treatment groups daily received prednisolone (2 mg/kg, orally) or Thymol (100 mg/kg, orally) for 10 consecutive days. Then, the rats were euthanized and tissue specimens were collected for evaluation of cyclooxygenase2 (COX-2) expression by immunohistochemistry. Furthermore, the levels of total protein, nitric oxide, myeloperoxidase, malondialdehyde, IL-1, IL-6, and TNF-α were monitored in colonic homogenates. Eventually, the relative mRNA expression of Iκ Bα and NF-κ Bp65 was investigated using reverse-transcriptase PCR (RT-PCR) in colonic homogenates. Results: Both medications could reduce the mortality rate and the clinical scores of Ulcerative colitis. The COX-2 expression was significantly reduced in the colons of Thymol-treated animals compared to the prednisolone group. Also, the myeloperoxidase activity, nitric oxide level and malondialdehyde intensity were decreased in the colons of Thymol-treated animals to a greater extent compared to the prednisolone group. Moreover, the total protein content of guts showed significant increases in the guts of Thymoltreated animals in comparison to the prednisolone group. Nonetheless, Thymol significantly reduced the levels of IL-6, and IL-1 compared to prednisolone. Both medications caused a significant decrease in the mRNA level of NF-κ Bp65, though the mRNA level of Iκ Bα did not show significant changes between the groups. Conclusion: Thymol may be a promising agent to ameliorate Ulcerative colitis.

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    APA: Copy

    Tahmasebi, Pourya, ABTAHI FROUSHANI, SEYYED MEYSAM, & AFZAL AHANGARAN, NAHIDEH. (2019). Thymol has beneficial effects on the experimental model of ulcerative colitis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(6), 538-550. SID. https://sid.ir/paper/326539/en

    Vancouver: Copy

    Tahmasebi Pourya, ABTAHI FROUSHANI SEYYED MEYSAM, AFZAL AHANGARAN NAHIDEH. Thymol has beneficial effects on the experimental model of ulcerative colitis. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(6):538-550. Available from: https://sid.ir/paper/326539/en

    IEEE: Copy

    Pourya Tahmasebi, SEYYED MEYSAM ABTAHI FROUSHANI, and NAHIDEH AFZAL AHANGARAN, “Thymol has beneficial effects on the experimental model of ulcerative colitis,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 6, pp. 538–550, 2019, [Online]. Available: https://sid.ir/paper/326539/en

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