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Information Journal Paper

Title

Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial

Pages

  505-516

Keywords

Burning mouth syndrome (BMS) 

Abstract

 Objective: Burning mouth syndrome (BMS) is a debilitating disorder with few limited treatment modalities. Because of the proven association between BMS symptoms, and Depression and Anxiety, treatment modalities that alleviate the two latter etiologic factors can be clinically effective. Thus, owing to the antidepressant and potential analgesic effects of Crocin (as an active constituent of saffron), the present study was performed to compare the effect of Crocin and Citalopram (as control) on BMS symptoms and Depression/Anxiety in patients with BMS. Materials and Methods: The present double-blind randomized clinical trial was carried out on BMS patients. Patients were randomly divided into Citalopram (n=21) and Crocin (n=26) groups and treated for 11 weeks. BMS symptoms (based on Visual Analysis Scale (VAS)), as well as Anxiety and Depression (based on Hamilton questionnaire) were evaluated at baseline and during the treatment period. Mann-Whitney, Chi-Square test, Independent ttest, Friedman, and Spearman correlation were employed for statistical analysis. Results: Our findings showed a significant effect for Crocin on the severity of BMS symptoms, Anxiety and Depression in BMS patients. Conclusion: Crocin can be considered for treatment of BMS subjects with concurrent Anxiety and/or Depression.

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    Cite

    APA: Copy

    PAKFETRAT, ATESSA, TALEBI, MEHDI, DALIRSANI, ZOHREH, MOHAJERI, AHMAD, ZAMANI, ROYA, & GHAZI, ALA. (2019). Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(6), 505-516. SID. https://sid.ir/paper/326541/en

    Vancouver: Copy

    PAKFETRAT ATESSA, TALEBI MEHDI, DALIRSANI ZOHREH, MOHAJERI AHMAD, ZAMANI ROYA, GHAZI ALA. Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(6):505-516. Available from: https://sid.ir/paper/326541/en

    IEEE: Copy

    ATESSA PAKFETRAT, MEHDI TALEBI, ZOHREH DALIRSANI, AHMAD MOHAJERI, ROYA ZAMANI, and ALA GHAZI, “Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 6, pp. 505–516, 2019, [Online]. Available: https://sid.ir/paper/326541/en

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