ALTERATION OF RAT RENAL ANTIOXIDANTS IN AN IN VIVO MODEL OF RENAL ISCHEMIA/REPERFUSION

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ZAHMATKESH M.; KADKHODAEI MEHRI; GHAZNAVI R.

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Journal: KOWSAR MEDICAL JOURNAL Year:2006 | Volume:11 | Issue:3 Page(s): 217-223

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Title

ALTERATION OF RAT RENAL ANTIOXIDANTS IN AN IN VIVO MODEL OF RENAL ISCHEMIA/REPERFUSION

Author(s)

ZAHMATKESH M. | KADKHODAEI MEHRI | GHAZNAVI R. | Issue Writer Certificate

Keywords

KIDNEYQ3

ISCHEMIA-REPERFUSIONQ3

GLUTATHIONEQ3

SUPEROXIDE DISMUTASEQ3

ALPHA-TOCOPHEROLQ3

Abstract

Objective: This study was designed to investigate the alteration of renal SOD, GSH and ALPHA-TOCOPHEROL in an in vivo model of renal ischemia/reperfusion (IR).Materials and Methods: Experiments were performed on pentobarbital anesthetized rats. After tracheotomy, the right femoral artery was cannulated and the mean arterial pressure was recorded. A midline laparatomy was performed, and the renal arteries were carefully separated from surrounding tissues. In IR group, rats were subjected to bilateral renal artery occlusion for 40 min followed by 6h reperfusion.Results: IR caused significant decrease in renal GSH and SOD compared to control group. There were no significant changes in renal and plasma a-tocopherol levels.Conclusion: In this work, renal antioxidants were demonstrated changing in a systematically organized relationship under ISCHEMIA-REPERFUSION. This graded utilization of antioxidants should be considered in antioxidant therapy.

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APA: Copy

ZAHMATKESH, M., KADKHODAEI, MEHRI, & GHAZNAVI, R.. (2006). ALTERATION OF RAT RENAL ANTIOXIDANTS IN AN IN VIVO MODEL OF RENAL ISCHEMIA/REPERFUSION. KOWSAR MEDICAL JOURNAL, 11(3), 217-223. SID. https://sid.ir/paper/32725/en

Vancouver: Copy

ZAHMATKESH M., KADKHODAEI MEHRI, GHAZNAVI R.. ALTERATION OF RAT RENAL ANTIOXIDANTS IN AN IN VIVO MODEL OF RENAL ISCHEMIA/REPERFUSION. KOWSAR MEDICAL JOURNAL[Internet]. 2006;11(3):217-223. Available from: https://sid.ir/paper/32725/en

IEEE: Copy

M. ZAHMATKESH, MEHRI KADKHODAEI, and R. GHAZNAVI, “ALTERATION OF RAT RENAL ANTIOXIDANTS IN AN IN VIVO MODEL OF RENAL ISCHEMIA/REPERFUSION,” KOWSAR MEDICAL JOURNAL, vol. 11, no. 3, pp. 217–223, 2006, [Online]. Available: https://sid.ir/paper/32725/en

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