MULTIVISCERAL TRANSPLANTATION FOR THE TREATMENT OF INTRA-ABDOMINAL TUMORS

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NIKEGHBALIAN S.; BAHREINI A.; SHAMSAEEFAR A.R.; FAKHAR N.; KAZEMI K.; MOTAZEDIAN N.; MALEK HOSSEINI S.A.

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Journal: International Journal of Organ Transplantation Medicine Year:2015 | Volume:6 | Issue:3 Page(s): 137-138

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Title

MULTIVISCERAL TRANSPLANTATION FOR THE TREATMENT OF INTRA-ABDOMINAL TUMORS

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Abstract

Background: Some intra-abdominal or retroperitoneal tumors such as low-grade slow-growing malignancies may seem unresectable due to major vessel encasement or presence of intra-abdominal dissemination. However, the slow growth rate and to some extent long life expectancy of the patients urge us to find some strategies to cure the patients or at least achieve tumor remission or symptom palliation. En bloc resection, followed by multivisceral or liver-sparing modified multivisceral transplantation has recently been used for the treatment of these patients.Methods: Between May 2010 and October 2012, 3 multivisceral and 3 modified multivisceral transplantations were performed in 6 patients (mean age: 32, range: 14–55 years) with some slow-growing intra-abdominal malignancies (2 neuroendocrine tumors, 2 gastrointestinal stromal tumors, 1 desmoid tumor, and 1 low-grade sarcoma).Results: All patients survived the procedure. One patient died of pancytopenia 2 months after transplantation; another died with pulmonary emboli 4 months post-transplantation. The remaining 4 patients are alive without any evidence of disease recurrence.Conclusion: Although large intra-abdominal desmoid tumors, well-differentiated neuroendocrine tumors, and gastrointestinal stromal tumors are slow growing, they tend to invade locally, especially to the mesenteric root and/or celiac axis and other abdominal viscera. Complete resection followed by multivisceral transplantation could be a therapeutic option for these advanced tumors.

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APA: Copy

NIKEGHBALIAN, S., BAHREINI, A., SHAMSAEEFAR, A.R., FAKHAR, N., KAZEMI, K., MOTAZEDIAN, N., & MALEK HOSSEINI, S.A.. (2015). MULTIVISCERAL TRANSPLANTATION FOR THE TREATMENT OF INTRA-ABDOMINAL TUMORS. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, 6(3), 137-138. SID. https://sid.ir/paper/327532/en

Vancouver: Copy

NIKEGHBALIAN S., BAHREINI A., SHAMSAEEFAR A.R., FAKHAR N., KAZEMI K., MOTAZEDIAN N., MALEK HOSSEINI S.A.. MULTIVISCERAL TRANSPLANTATION FOR THE TREATMENT OF INTRA-ABDOMINAL TUMORS. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE[Internet]. 2015;6(3):137-138. Available from: https://sid.ir/paper/327532/en

IEEE: Copy

S. NIKEGHBALIAN, A. BAHREINI, A.R. SHAMSAEEFAR, N. FAKHAR, K. KAZEMI, N. MOTAZEDIAN, and S.A. MALEK HOSSEINI, “MULTIVISCERAL TRANSPLANTATION FOR THE TREATMENT OF INTRA-ABDOMINAL TUMORS,” INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, vol. 6, no. 3, pp. 137–138, 2015, [Online]. Available: https://sid.ir/paper/327532/en

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