MU OPIOID RECEPTOR GENE: NEW POINT MUTATIONS IN OPIOID ADDICTS

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DINARVAND AMIN; GOODARZI ALI; VOUSOOGHI NASIM; HASHEMI MEHRDAD; DINARVAND RASOUL; OSTADZADEH FAHIMEH; KHOSHZABAN AHAD; ZARRINDAST MOHAMMAD REZA

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Journal: Basic and Clinical Neuroscience Year:2014 | Volume:5 | Issue:1 Page(s): 18-21

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Title

MU OPIOID RECEPTOR GENE: NEW POINT MUTATIONS IN OPIOID ADDICTS

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Keywords

ADDICTION

OPRM1 GENE

POLYMORPHISM

Abstract

Introduction: Association between single-nucleotide POLYMORPHISMs (SNPs) in mu opioid receptor gene and drug ADDICTION has been shown in various studies. Here, we have evaluated the existence of POLYMORPHISMs in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid ADDICTION.Methods: 79 opioid-dependent subjects (55 males, 24 females) and 134 non-addict or control individuals (74 males, 60 females) participated in the study. Genomic DNA was extracted from volunteers’ peripheral blood and exon 3 of the mu opioid receptor gene was amplified by polymerase chain reaction (PCR) whose products were then sequenced.Results: Three different heterozygote POLYMORPHISMs were observed in 3 male individuals: 759T>C and 877G>A mutations were found in 2 control volunteers and 1043G>C substitution was observed in an opioid-addicted subject. Association between genotype and opioid ADDICTION for each mutation was not statistically significant.Discussion: It seems that the sample size used in our study is not enough to confirm or reject any association between 759T>C, 877G>A and 1043G>C substitutions in exon 3 of the mu opioid receptor gene and opioid ADDICTION susceptibility in Iranian population.

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APA: Copy

DINARVAND, AMIN, GOODARZI, ALI, VOUSOOGHI, NASIM, HASHEMI, MEHRDAD, DINARVAND, RASOUL, OSTADZADEH, FAHIMEH, KHOSHZABAN, AHAD, & ZARRINDAST, MOHAMMAD REZA. (2014). MU OPIOID RECEPTOR GENE: NEW POINT MUTATIONS IN OPIOID ADDICTS. BASIC AND CLINICAL NEUROSCIENCE, 5(1), 18-21. SID. https://sid.ir/paper/327669/en

Vancouver: Copy

DINARVAND AMIN, GOODARZI ALI, VOUSOOGHI NASIM, HASHEMI MEHRDAD, DINARVAND RASOUL, OSTADZADEH FAHIMEH, KHOSHZABAN AHAD, ZARRINDAST MOHAMMAD REZA. MU OPIOID RECEPTOR GENE: NEW POINT MUTATIONS IN OPIOID ADDICTS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(1):18-21. Available from: https://sid.ir/paper/327669/en

IEEE: Copy

AMIN DINARVAND, ALI GOODARZI, NASIM VOUSOOGHI, MEHRDAD HASHEMI, RASOUL DINARVAND, FAHIMEH OSTADZADEH, AHAD KHOSHZABAN, and MOHAMMAD REZA ZARRINDAST, “MU OPIOID RECEPTOR GENE: NEW POINT MUTATIONS IN OPIOID ADDICTS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 1, pp. 18–21, 2014, [Online]. Available: https://sid.ir/paper/327669/en

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