EFFECTS OF VENLAFAXINE AND METHADONE ALONE AND IN COMBINATION WITH SPONTANEOUS MORPHINE WITHDRAWAL SYNDROME AND PAIN SENSATION IN RATS

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FADAEI KENARSARY MEISAM; FARBOOD YAGHOOB; MANSOURI SEYED MOHAMMAD TAGHI; FATHI MOGHADDAM HADI

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Journal: Basic and Clinical Neuroscience Year:2015 | Volume:6 | Issue:1 Page(s): 21-28

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Title

EFFECTS OF VENLAFAXINE AND METHADONE ALONE AND IN COMBINATION WITH SPONTANEOUS MORPHINE WITHDRAWAL SYNDROME AND PAIN SENSATION IN RATS

Author(s)

FADAEI KENARSARY MEISAM | FARBOOD YAGHOOB | MANSOURI SEYED MOHAMMAD TAGHI | FATHI MOGHADDAM HADI | Issue Writer Certificate

Keywords

MORPHINE WITHDRAWAL SYNDROME

METHADONE

VENLAFAXINE

PAIN

RAT

Abstract

Introduction: METHADONE has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by VENLAFAXINE as an antidepressant.On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with PAIN sensitivity. Therefore the present study aimed to examine the effects of chronic METHADONE (70 mg/kg, in drinking water, 7 days), VENLAFAXINE (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous MORPHINE WITHDRAWAL SYNDROME and PAIN sensitivity.Methods: Twenty eight young male Sprague-Dawley RATs were randomly divided into 4 groups: control, VENLAFAXINE treated, METHADONE treated and VENLAFAXINE+methadone treated.Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by METHADONE or its vehicle administration. Second intervention was VENLAFAXINE or its vehicle injection. Then final withdrawal behaviors and tail flick test were performed.Results: Combination of chronic METHADONE substitution and VENLAFAXINE administration, significantly reduced freezing behavior of spontaneous MORPHINE WITHDRAWAL SYNDROME (P<0.01, 379±144%). Chronic METHADONE administration (P<0.05, 35±8% difference with VENLAFAXINE treated group) induced hyperalgesia. A positive correlation (P=0.001, +63%) was observed between the animals final freezing scores and their response latencies to the PAINful stimulus.Discussion: Combination of chronic METHADONE and VENLAFAXINE administrations reduces freezing withdrawal behavior. Further investigations on analgesic interventions are needed to overcome this hyperalgesia.

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APA: Copy

FADAEI KENARSARY, MEISAM, FARBOOD, YAGHOOB, MANSOURI, SEYED MOHAMMAD TAGHI, & FATHI MOGHADDAM, HADI. (2015). EFFECTS OF VENLAFAXINE AND METHADONE ALONE AND IN COMBINATION WITH SPONTANEOUS MORPHINE WITHDRAWAL SYNDROME AND PAIN SENSATION IN RATS. BASIC AND CLINICAL NEUROSCIENCE, 6(1), 21-28. SID. https://sid.ir/paper/327778/en

Vancouver: Copy

FADAEI KENARSARY MEISAM, FARBOOD YAGHOOB, MANSOURI SEYED MOHAMMAD TAGHI, FATHI MOGHADDAM HADI. EFFECTS OF VENLAFAXINE AND METHADONE ALONE AND IN COMBINATION WITH SPONTANEOUS MORPHINE WITHDRAWAL SYNDROME AND PAIN SENSATION IN RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2015;6(1):21-28. Available from: https://sid.ir/paper/327778/en

IEEE: Copy

MEISAM FADAEI KENARSARY, YAGHOOB FARBOOD, SEYED MOHAMMAD TAGHI MANSOURI, and HADI FATHI MOGHADDAM, “EFFECTS OF VENLAFAXINE AND METHADONE ALONE AND IN COMBINATION WITH SPONTANEOUS MORPHINE WITHDRAWAL SYNDROME AND PAIN SENSATION IN RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 6, no. 1, pp. 21–28, 2015, [Online]. Available: https://sid.ir/paper/327778/en

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