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Information Journal Paper

Title

MODULATION OF DIFFERENT PHASES OF FORMALIN TEST BY FORCE SWIM STRESS

Pages

  303-307

Abstract

 Introduction: The FORMALIN TEST is the most accepted chemical test for evaluation of nociception. It requires the injection of an adequate amount of formalin into the surface of the hindpaw. FORMALIN TEST consists of phase 1 (0-7 min) and phase 2 (15-60) in which the animal shows PAINful behaviors. These phases are separated with a quiet phase named INTERPHASE, in which the nociceptive responses are decreased or completely disappeared.Methods: The goal of the current study was to evaluate the effects of SWIM STRESS at different heights of water on different phases of the FORMALIN TEST in male rats.Results: SWIM STRESS decreased nociceptive behaviors in first phase and prolonged INTERPHASE or delayed the start of second phase in a water height dependent manner. SWIM STRESS in 25 and 50cm completely abolished the nociceptive behaviors in phase 1.Discussion: The present results showed different PAIN modulation during different phases of the FORMALIN TEST and elucidated the impact of SWIM STRESS on duration of INTERPHASE. INTERPHASE considered as an inactive period, but a recent research has shown that active inhibitory mechanisms are involved in the modulation of PAIN during this period. Therefore, SWIM STRESS may be considered as a useful tool for study of the basic inhibitory mechanisms underlying attenuation of nociceptive behaviors between phase 1 and 2 of the FORMALIN TEST.

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    APA: Copy

    MOHAMMAD ZADEH, MOHAMMAD, AZHDARI ZARMEHRI, HASSAN, MOSAVI, FAEZE, HAGHDOOST YAZDI, HASHEM, NAZERI, MASOUD, & SHABANI, MOHAMMAD. (2014). MODULATION OF DIFFERENT PHASES OF FORMALIN TEST BY FORCE SWIM STRESS. BASIC AND CLINICAL NEUROSCIENCE, 5(4), 303-307. SID. https://sid.ir/paper/327787/en

    Vancouver: Copy

    MOHAMMAD ZADEH MOHAMMAD, AZHDARI ZARMEHRI HASSAN, MOSAVI FAEZE, HAGHDOOST YAZDI HASHEM, NAZERI MASOUD, SHABANI MOHAMMAD. MODULATION OF DIFFERENT PHASES OF FORMALIN TEST BY FORCE SWIM STRESS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(4):303-307. Available from: https://sid.ir/paper/327787/en

    IEEE: Copy

    MOHAMMAD MOHAMMAD ZADEH, HASSAN AZHDARI ZARMEHRI, FAEZE MOSAVI, HASHEM HAGHDOOST YAZDI, MASOUD NAZERI, and MOHAMMAD SHABANI, “MODULATION OF DIFFERENT PHASES OF FORMALIN TEST BY FORCE SWIM STRESS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 4, pp. 303–307, 2014, [Online]. Available: https://sid.ir/paper/327787/en

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