REVIEW PAPER: ASSOCIATION OF TRANSFORMING GROWTH FACTOR BETA-1 -509C/T GENE POLYMORPHISM WITH ISCHEMIC STROKE: A META ANALYSIS

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KUMAR PRADEEP; KUMAR AMIT; SRIVASTAVA MUKESH KUMAR; MISRA SHUBHAM; PANDIT AWADH KISHOR; PRASAD KAMESHWAR

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Journal: Basic and Clinical Neuroscience Year:2016 | Volume:7 | Issue:2 Page(s): 91-96

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Title

REVIEW PAPER: ASSOCIATION OF TRANSFORMING GROWTH FACTOR BETA-1 -509C/T GENE POLYMORPHISM WITH ISCHEMIC STROKE: A META ANALYSIS

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Keywords

TRANSFORMING GROWTH FACTOR BETA

CYTOKINE

INFLAMMATION

CEREBRAL INFARCTION

ISCHEMIC STROKE

SINGLE NUCLEOTIDE POLYMORPHISM

METAANALYSIS

Abstract

Introduction: Transforming Growth Factor-Beta 1 (TGF- b 1) is a pleiotropic CYTOKINE with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ISCHEMIC STROKE (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF- b 1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF- b 1 and susceptibility to IS.Methods: A review of literature for eligible genetic association Studies published before October 20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared, and Chi-squared tests.Results: A total of 2 studies involving 614 cases and 617 controls were found. The overall estimates did not show any significant relation between TGF- b 1-509C/T polymorphism and risk of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06, 95%CI=0.55 to 2.04; P=0.86).Conclusion: This meta-analysis showed that TGF- b 1-509C/T gene polymorphism has no significant association with the susceptibility of IS. Further well-designed prospective studies with larger sample size are needed to confirm these findings.

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APA: Copy

KUMAR, PRADEEP, KUMAR, AMIT, SRIVASTAVA, MUKESH KUMAR, MISRA, SHUBHAM, PANDIT, AWADH KISHOR, & PRASAD, KAMESHWAR. (2016). REVIEW PAPER: ASSOCIATION OF TRANSFORMING GROWTH FACTOR BETA-1 -509C/T GENE POLYMORPHISM WITH ISCHEMIC STROKE: A META ANALYSIS. BASIC AND CLINICAL NEUROSCIENCE, 7(2), 91-96. SID. https://sid.ir/paper/327809/en

Vancouver: Copy

KUMAR PRADEEP, KUMAR AMIT, SRIVASTAVA MUKESH KUMAR, MISRA SHUBHAM, PANDIT AWADH KISHOR, PRASAD KAMESHWAR. REVIEW PAPER: ASSOCIATION OF TRANSFORMING GROWTH FACTOR BETA-1 -509C/T GENE POLYMORPHISM WITH ISCHEMIC STROKE: A META ANALYSIS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2016;7(2):91-96. Available from: https://sid.ir/paper/327809/en

IEEE: Copy

PRADEEP KUMAR, AMIT KUMAR, MUKESH KUMAR SRIVASTAVA, SHUBHAM MISRA, AWADH KISHOR PANDIT, and KAMESHWAR PRASAD, “REVIEW PAPER: ASSOCIATION OF TRANSFORMING GROWTH FACTOR BETA-1 -509C/T GENE POLYMORPHISM WITH ISCHEMIC STROKE: A META ANALYSIS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 7, no. 2, pp. 91–96, 2016, [Online]. Available: https://sid.ir/paper/327809/en

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