THE MODULATORY ROLE OF OREXIN 1 RECEPTOR IN CA1 ON OROFACIAL PAIN-INDUCED LEARNING AND MEMORY DEFICITS IN RATS

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Kooshki Razieh; ABBASNEJAD MEHDI; ESMAEILI MAHANI SAEED; RAOOF MARYAM

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Journal: Basic and Clinical Neuroscience Year:2017 | Volume:8 | Issue:3 Page(s): 213-221

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Title

THE MODULATORY ROLE OF OREXIN 1 RECEPTOR IN CA1 ON OROFACIAL PAIN-INDUCED LEARNING AND MEMORY DEFICITS IN RATS

Author(s)

Kooshki Razieh | ABBASNEJAD MEHDI | ESMAEILI MAHANI SAEED | RAOOF MARYAM | Issue Writer Certificate

Keywords

OROFACIAL PAIN

OREXIN 1 RECEPTOR

CA1

LEARNING AND MEMORY

CAPSAICIN

Abstract

Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of OREXIN 1 RECEPTOR (OX1R) in pain pathways as well as LEARNING AND MEMORY processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial LEARNING AND MEMORY of rats following CAPSAICIN-induced OROFACIAL PAIN.Methods: OROFACIAL PAIN was induced by subcutaneous intra lip injection of CAPSAICIN (100 mg). CA1 administration of orexin A and its selective antagonist (SB-334867-A) were performed 20 minutes prior to CAPSAICIN injection. Learning and spatial memory performances were assessed by Morris Water Maze (MWM) task.Results: CAPSAICIN treated rats showed impairment in spatial LEARNING AND MEMORY. In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated LEARNING AND MEMORY impairment in CAPSAICIN-treated rats. Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated LEARNING AND MEMORY loss in CAPSAICIN-treated rats.Conclusion: The obtained results indicated that CA1 OX1R may be involved in modulation of CAPSAICIN –induced spatial LEARNING AND MEMORY impairment.

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APA: Copy

Kooshki, Razieh, ABBASNEJAD, MEHDI, ESMAEILI MAHANI, SAEED, & RAOOF, MARYAM. (2017). THE MODULATORY ROLE OF OREXIN 1 RECEPTOR IN CA1 ON OROFACIAL PAIN-INDUCED LEARNING AND MEMORY DEFICITS IN RATS. BASIC AND CLINICAL NEUROSCIENCE, 8(3), 213-221. SID. https://sid.ir/paper/327841/en

Vancouver: Copy

Kooshki Razieh, ABBASNEJAD MEHDI, ESMAEILI MAHANI SAEED, RAOOF MARYAM. THE MODULATORY ROLE OF OREXIN 1 RECEPTOR IN CA1 ON OROFACIAL PAIN-INDUCED LEARNING AND MEMORY DEFICITS IN RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(3):213-221. Available from: https://sid.ir/paper/327841/en

IEEE: Copy

Razieh Kooshki, MEHDI ABBASNEJAD, SAEED ESMAEILI MAHANI, and MARYAM RAOOF, “THE MODULATORY ROLE OF OREXIN 1 RECEPTOR IN CA1 ON OROFACIAL PAIN-INDUCED LEARNING AND MEMORY DEFICITS IN RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 3, pp. 213–221, 2017, [Online]. Available: https://sid.ir/paper/327841/en

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