CROSS STATE-DEPENDENT LEARNING INTERACTION BETWEEN SCOPOLAMINE AND MORPHINE IN MICE: THE ROLE OF DORSAL HIPPOCAMPUS

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MALEKI MORTEZA; HASSANPOUR EZATTI MAJID; NAVAEIAN MAJID

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Journal: Basic and Clinical Neuroscience Year:2017 | Volume:8 | Issue:3 Page(s): 193-201

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Title

CROSS STATE-DEPENDENT LEARNING INTERACTION BETWEEN SCOPOLAMINE AND MORPHINE IN MICE: THE ROLE OF DORSAL HIPPOCAMPUS

Author(s)

MALEKI MORTEZA | HASSANPOUR EZATTI MAJID | NAVAEIAN MAJID | Issue Writer Certificate

Keywords

MORPHINE

SCOPOLAMINE

CA1 REGION

HIPPOCAMPAL

DEPENDENCY

MICE

Abstract

Introduction: The current study aimed at investigating the existence of the cross state-dependent learning between MORPHINE and SCOPOLAMINE (SCO) in MICE by passive avoidance method, pointing to the role of CA1 area.Methods: The effects of pre-training SCO (0.75, 1.5, and 3 mg, Intra-CA1), or MORPHINE (1, 3, and 6 mg/kg, intraperitoneal (i.p.) was evaluated on the retrieval of passive avoidance learning using step-down task in MICE (n=10). Then, the effect of pretest administration of MORPHINE (1.5, 3, and 6 mg/kg, i.p.) was examined on passive avoidance retrieval impairment induced by pre-training SCO (3 mg/mice, Intra-CA1). Next, the effect of pretest Intra-CA1 injection of SCOPOLAMINE (0.75, 1.5, and 3 mg/mice) was evaluated on MORPHINE (6 mg/kg, i.p.) pre-training deficits in this task in MICE.Results: The pre-training Intra-CA1 injection of SCOPOLAMINE (1.5 and 3 mg/mouse), or MORPHINE (3 and 6 mg/kg, i.p.) impaired the avoidance memory retrieval when it was tested 24 hours later. Pretest injection of both drugs improved its pre-training impairing effects on MICE memory. Moreover, the amnesia induced by the pre-training injections of SCOPOLAMINE (3 mg/mice) was restored significantly (P<0.01) by pretest injections of MORPHINE (3 and 6 mg/kg, i.p.). Similarly, pretest injection of SCOPOLAMINE (3 mg/mice) restored amnesia induced by the pre-training injections of MORPHINE (6 mg/kg, i.p.), significantly (P<0.01).Conclusion: The current study findings indicated a cross state-dependent learning between SCO and MORPHINE at CA1 level. Therefore, it seems that muscarinic and opioid receptors may act reciprocally on modulation of passive avoidance memory retrieval, at the level of dorsal hippocampus, in MICE.

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APA: Copy

MALEKI, MORTEZA, HASSANPOUR EZATTI, MAJID, & NAVAEIAN, MAJID. (2017). CROSS STATE-DEPENDENT LEARNING INTERACTION BETWEEN SCOPOLAMINE AND MORPHINE IN MICE: THE ROLE OF DORSAL HIPPOCAMPUS. BASIC AND CLINICAL NEUROSCIENCE, 8(3), 193-201. SID. https://sid.ir/paper/327842/en

Vancouver: Copy

MALEKI MORTEZA, HASSANPOUR EZATTI MAJID, NAVAEIAN MAJID. CROSS STATE-DEPENDENT LEARNING INTERACTION BETWEEN SCOPOLAMINE AND MORPHINE IN MICE: THE ROLE OF DORSAL HIPPOCAMPUS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(3):193-201. Available from: https://sid.ir/paper/327842/en

IEEE: Copy

MORTEZA MALEKI, MAJID HASSANPOUR EZATTI, and MAJID NAVAEIAN, “CROSS STATE-DEPENDENT LEARNING INTERACTION BETWEEN SCOPOLAMINE AND MORPHINE IN MICE: THE ROLE OF DORSAL HIPPOCAMPUS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 3, pp. 193–201, 2017, [Online]. Available: https://sid.ir/paper/327842/en

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