RESEARCH PAPER: THE ANTI-PARKINSONISM EFFECTS OF KATP CHANNEL BLOCKADE IN THE 6-HYDROXYDOPAMINE-INDUCED ANIMAL MODEL: THE ROLE OF OXIDATIVE STRESS

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PIRI HOSSEIN; HAGHDOOST YAZDI HASHEM; FRAIDOUNI NEGIN; Dargahi Tahereh; YAGHOUBIDOUST MOHAMADHOSEIN; AZADMEHR ABBAS

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Journal: Basic and Clinical Neuroscience Year:2017 | Volume:8 | Issue:3 Page(s): 183-191

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Title

RESEARCH PAPER: THE ANTI-PARKINSONISM EFFECTS OF KATP CHANNEL BLOCKADE IN THE 6-HYDROXYDOPAMINE-INDUCED ANIMAL MODEL: THE ROLE OF OXIDATIVE STRESS

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Keywords

PARKINSON DISEASE

6-HYDROXYDOPAMINE

GLIBENCLAMIDE

B VITAMINS

MALONDIALDEHYDE

Abstract

Introduction: Studies suggest that ATP-sensitive potassium (KATP) channels are a potential pharmacotherapeutic target for neuroprotection in neurodegenerative diseases. The current study aimed at evaluating the effect of pretreatment with GLIBENCLAMIDE (Glib) and B VITAMINS supplement on the severity of behavioral symptoms in 6-HYDROXYDOPAMINE (OHDA) -induced Parkinsonism. Also MALONDIALDEHYDE (MDA) concentration was measured in the blood and brain suspensions to find probable neuroprotective mechanism of Glib.Methods: The 6-OHDA was injected into striatum of rats by stereotaxic surgery. Treatment with Glib and B VITAMINS was started before the surgery and continued up to 3 weeks after that. Development and severity of Parkinsonism were evaluated by conventional behavioral tests. MDA values were measured spectrophotometrically using thiobarbituric acid and MDA standard curve.Results: Pretreatments with Glib, at both doses of 1 and 5 mg/kg or B VITAMINS significantly ameliorated severity of the behavioral symptoms. Pretreatment with a combination of Glib and B VITAMINS was more effective than pretreatment with Glib or B VITAMINS alone. Also, pretreatment with B VITAMINS, Glib, or a combination of them reduced MDA concentration in the brain suspensions. Decrease in MDA concentration in the group of rats that received a combination of B VITAMINS and Glib was more prominent than that of the Glib groups.Conclusion: As severity of the behavioral symptoms in the 6-OHDA-induced Parkinsonism reflects the degree of the lesion in Substantia Nigra (SN) dopaminergic neurons, it is suggested that Glib pretreatment has neuroprotective effect against 6-OHDA-induced neurotoxicity. The current study data also showed that this effect may be mediated by antioxidant effect of Glib.

Cites

Dopaminergic Neuroprotection with Ginkgolide in 6-Hydroxydopamine Rat Parkinson’ s Disease Model

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APA: Copy

PIRI, HOSSEIN, HAGHDOOST YAZDI, HASHEM, FRAIDOUNI, NEGIN, Dargahi, Tahereh, YAGHOUBIDOUST, MOHAMADHOSEIN, & AZADMEHR, ABBAS. (2017). RESEARCH PAPER: THE ANTI-PARKINSONISM EFFECTS OF K_ATP CHANNEL BLOCKADE IN THE 6-HYDROXYDOPAMINE-INDUCED ANIMAL MODEL: THE ROLE OF OXIDATIVE STRESS. BASIC AND CLINICAL NEUROSCIENCE, 8(3), 183-191. SID. https://sid.ir/paper/327848/en

Vancouver: Copy

PIRI HOSSEIN, HAGHDOOST YAZDI HASHEM, FRAIDOUNI NEGIN, Dargahi Tahereh, YAGHOUBIDOUST MOHAMADHOSEIN, AZADMEHR ABBAS. RESEARCH PAPER: THE ANTI-PARKINSONISM EFFECTS OF K_ATP CHANNEL BLOCKADE IN THE 6-HYDROXYDOPAMINE-INDUCED ANIMAL MODEL: THE ROLE OF OXIDATIVE STRESS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(3):183-191. Available from: https://sid.ir/paper/327848/en

IEEE: Copy

HOSSEIN PIRI, HASHEM HAGHDOOST YAZDI, NEGIN FRAIDOUNI, Tahereh Dargahi, MOHAMADHOSEIN YAGHOUBIDOUST, and ABBAS AZADMEHR, “RESEARCH PAPER: THE ANTI-PARKINSONISM EFFECTS OF K_ATP CHANNEL BLOCKADE IN THE 6-HYDROXYDOPAMINE-INDUCED ANIMAL MODEL: THE ROLE OF OXIDATIVE STRESS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 3, pp. 183–191, 2017, [Online]. Available: https://sid.ir/paper/327848/en

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