A CLINICAL EVALUATION OF TOPICAL 5-AMINOSALICYLATE IN RECURRENT APHTHOUS STOMATITIS

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GHODRATNAMA F.; POORHEIDARI GH.

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Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2000 | Volume:5 | Issue:Part 3 Page(s): 183-188

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Information Journal Paper

Title

A CLINICAL EVALUATION OF TOPICAL 5-AMINOSALICYLATE IN RECURRENT APHTHOUS STOMATITIS

Author(s)

GHODRATNAMA F. | POORHEIDARI GH. | Issue Writer Certificate

Keywords

5-AMINOSALISILATEQ4

RECURRENT APHTHOUS STOMATITISQ4

Abstract

The aim of this study was to investigate the effect of topical 5-AMINOSALISILATE (5ASA) in RECURRENT APHTHOUS STOMATITIS (RAS) in a double-blind cross over study. Sixty-six patients with RAS were randomly allocated to receive either 5ASA or placebo for one month following a one month baseline period Patients were then crossed over after two week wash-out period. Forty-two patients completed the study. All patients kept a daily record of pain, number, size, duration and localization of ulcers. The number of ulcers and the associated pain decreased between the first and second period (P < 0.05 Mann- Whitney U test) regardless of whether 5ASA or placebo was used. No significant differences were found between SASA and placebo with respect to recorded number, size, duration or pain of ulcers. Analysis of the first period only, as a double-blind trial, indicated that patient preference was for 5ASA with respect to pain and duration of ulcers. These data indicate that a double-blind cross-over study may not be a suitable method for investigating the effect of topical cream in RAS and that recording size, number and duration of ulcers on a daily basis may not be sensitive enough to reveal therapeutic differences. However 5ASA topical cream may be effective in the relief of pain and in decreasing the duration of ulcers in patients with RAS.

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APA: Copy

GHODRATNAMA, F., & POORHEIDARI, GH.. (2000). A CLINICAL EVALUATION OF TOPICAL 5-AMINOSALICYLATE IN RECURRENT APHTHOUS STOMATITIS. KOWSAR MEDICAL JOURNAL, 5(Part 3), 183-188. SID. https://sid.ir/paper/32786/en

Vancouver: Copy

GHODRATNAMA F., POORHEIDARI GH.. A CLINICAL EVALUATION OF TOPICAL 5-AMINOSALICYLATE IN RECURRENT APHTHOUS STOMATITIS. KOWSAR MEDICAL JOURNAL[Internet]. 2000;5(Part 3):183-188. Available from: https://sid.ir/paper/32786/en

IEEE: Copy

F. GHODRATNAMA, and GH. POORHEIDARI, “A CLINICAL EVALUATION OF TOPICAL 5-AMINOSALICYLATE IN RECURRENT APHTHOUS STOMATITIS,” KOWSAR MEDICAL JOURNAL, vol. 5, no. Part 3, pp. 183–188, 2000, [Online]. Available: https://sid.ir/paper/32786/en

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