GENES ENCODING GABA-? AND HT1D RECEPTORS IN BIPOLAR I (MANIC PHASE) PATIENTS

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MORADI MOHAMMAD REZA; SAIDIJAM MASSOUD; YADEGARAZARI REZA; JAHANGARD LEILA; SEIFI MARYAM; MATINNIA NASRIN; GHALEIHA ALI

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Journal: BASIC AND CLINICAL NEUROSCIENCE Year:2018 | Volume:9 | Issue:2 Page(s): 129-134

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Title

GENES ENCODING GABA-? AND HT1D RECEPTORS IN BIPOLAR I (MANIC PHASE) PATIENTS

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Keywords

GABA-?3

HT1D

SEROTONIN

BIPOLAR DISORDER

GENE EXPRESSION

Abstract

Introduction: According to the cumulative evidence, genes encoding GABA receptors inhibit neurotransmitters in CNS and are intricately involved in the pathogenesis of mood disorders. Based on this hypothesis, these genes may be expressed in bipolar patients. As a result, we evaluated the gene expressions of GABA-b3 and HT1D receptors to assess their associations with bipolar mood disorder.Methods: In this study, 22 patients with bipolar I disorder (single manic episode) and 22 healthy individuals were enrolled. All participants were older than 15 years and had referred to Farshchian Hospital, Hamadan, Iran. They were diagnosed based on DSM IV–TR criteria and young mania rating scale in order to determine the severity of mania by a psychiatrist as bipolar Type 1 disorder in manic episode. We evaluated the expression of GABA–b3 and HT1D receptor genes in peripheral blood mononuclear cells, using real-time RT-PCR analysis.Results: In our study, a reduction in the gene expression of GABA–β3 and HT1D receptors was observed in peripheral blood mononuclear cells of the patients with bipolar disorders compared to the healthy controls.Conclusion: The results of this study supports the hypothesis that the gene expression for serotonin and GABA receptors can be employed in elucidating the pathogenesis of bipolar disorders.

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APA: Copy

MORADI, MOHAMMAD REZA, SAIDIJAM, MASSOUD, YADEGARAZARI, REZA, JAHANGARD, LEILA, SEIFI, MARYAM, MATINNIA, NASRIN, & GHALEIHA, ALI. (2018). GENES ENCODING GABA-? AND HT1D RECEPTORS IN BIPOLAR I (MANIC PHASE) PATIENTS. BASIC AND CLINICAL NEUROSCIENCE, 9(2), 129-134. SID. https://sid.ir/paper/327860/en

Vancouver: Copy

MORADI MOHAMMAD REZA, SAIDIJAM MASSOUD, YADEGARAZARI REZA, JAHANGARD LEILA, SEIFI MARYAM, MATINNIA NASRIN, GHALEIHA ALI. GENES ENCODING GABA-? AND HT1D RECEPTORS IN BIPOLAR I (MANIC PHASE) PATIENTS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2018;9(2):129-134. Available from: https://sid.ir/paper/327860/en

IEEE: Copy

MOHAMMAD REZA MORADI, MASSOUD SAIDIJAM, REZA YADEGARAZARI, LEILA JAHANGARD, MARYAM SEIFI, NASRIN MATINNIA, and ALI GHALEIHA, “GENES ENCODING GABA-? AND HT1D RECEPTORS IN BIPOLAR I (MANIC PHASE) PATIENTS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 9, no. 2, pp. 129–134, 2018, [Online]. Available: https://sid.ir/paper/327860/en

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