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Information Journal Paper

Title

INTRODUCING TRANSTHYRETIN AS A DIFFERENTIALLY EXPRESSED PROTEIN IN WASHING SUBTYPE OF OBSESSIVE- COMPULSIVE DISORDER

Pages

  187-194

Keywords

OBSESSIVE-COMPULSIVE DISORDER (OCD) 
TRANSTHYRETIN (TTR) 
TWO-DIMENSIONAL GEL ELECTROPHORESIS (2DE) 

Abstract

 Introduction: Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder.Methods: In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, WASHING SUBTYPE before and after treatment with FLUOXETINE and comparing them with 20 healthy female controls.Results: One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Transthyretin (TTR) protein showed significant expression changes (fold change=1.7, P<0.05). While the expression level of TTR is significantly decreased in OCD patients before any treatments, the trend is partially normalized after treatment with FLUOXETINE in positive responders. Furthermore, TTR interaction profile shows that the proteins interacting with this protein may get affected as this protein expression trend changes in OCD patients.Conclusion: TTR can be considered for further studies to be validated as a potential biomarker for OCD.

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    APA: Copy

    ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, AREFI OSKOUIE, AFSANEH, MANSOURI, VAHID, HAMDIEH, MOSTAFA, NEJATI, NASER, HAMIDPOUR, MOHSEN, AHMADZADEH, ALIREZA, ROSTAMI NEJAT, MOHAMMAD, REZAEI TAVIRANI, MAJID, & MORTAZAVI TABATABAEI, SEYED ABDOLREZA. (2018). INTRODUCING TRANSTHYRETIN AS A DIFFERENTIALLY EXPRESSED PROTEIN IN WASHING SUBTYPE OF OBSESSIVE- COMPULSIVE DISORDER. BASIC AND CLINICAL NEUROSCIENCE, 9(3), 187-194. SID. https://sid.ir/paper/327869/en

    Vancouver: Copy

    ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, AREFI OSKOUIE AFSANEH, MANSOURI VAHID, HAMDIEH MOSTAFA, NEJATI NASER, HAMIDPOUR MOHSEN, AHMADZADEH ALIREZA, ROSTAMI NEJAT MOHAMMAD, REZAEI TAVIRANI MAJID, MORTAZAVI TABATABAEI SEYED ABDOLREZA. INTRODUCING TRANSTHYRETIN AS A DIFFERENTIALLY EXPRESSED PROTEIN IN WASHING SUBTYPE OF OBSESSIVE- COMPULSIVE DISORDER. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2018;9(3):187-194. Available from: https://sid.ir/paper/327869/en

    IEEE: Copy

    MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, AFSANEH AREFI OSKOUIE, VAHID MANSOURI, MOSTAFA HAMDIEH, NASER NEJATI, MOHSEN HAMIDPOUR, ALIREZA AHMADZADEH, MOHAMMAD ROSTAMI NEJAT, MAJID REZAEI TAVIRANI, and SEYED ABDOLREZA MORTAZAVI TABATABAEI, “INTRODUCING TRANSTHYRETIN AS A DIFFERENTIALLY EXPRESSED PROTEIN IN WASHING SUBTYPE OF OBSESSIVE- COMPULSIVE DISORDER,” BASIC AND CLINICAL NEUROSCIENCE, vol. 9, no. 3, pp. 187–194, 2018, [Online]. Available: https://sid.ir/paper/327869/en

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