PROTECTIVE EFFECTS OF MORIN HYDRATE ON ACUTE STRESS-INDUCED BEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN MICE

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OLONODE ELIZABETH TOYIN; ADERIBIGBE ADEGBUYI OLADELE; ADEOLUWA OLUSEGUN ADEBAYO; AJAYI ABAYOMI MAYOWA

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Journal: Basic and Clinical Neuroscience Year:2018 | Volume:9 | Issue:3 Page(s): 195-208

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Title

PROTECTIVE EFFECTS OF MORIN HYDRATE ON ACUTE STRESS-INDUCED BEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN MICE

Author(s)

OLONODE ELIZABETH TOYIN | ADERIBIGBE ADEGBUYI OLADELE | ADEOLUWA OLUSEGUN ADEBAYO | AJAYI ABAYOMI MAYOWA | Issue Writer Certificate

Keywords

MORIN HYDRATE

STRESS

RESTRAINT

ANXIETY

DEPRESSION

Abstract

Introduction: As STRESS affects the brain both physiologically and chemically, researchers try to find novel anti-stress compounds with beneficial therapeutic effects. In this regard, the effect of STRESS and its modulation by MORIN HYDRATE was studied using different acute models in mice.Methods: The models employed were anoxic tolerance, swimming endurance, and acute RESTRAINT test. MORIN HYDRATE or the vehicle was administered 30 minutes prior to each STRESS exposure while in the acute RESTRAINT test; the animals were pretreated for 7 days with MORIN HYDRATE, vehicle, imipramine, or diazepam before STRESS exposure. The measured parameters were the onset of convulsion and immobility time in the anoxic tolerance and swimming endurance test, respectively, while in the acute RESTRAINT test, the animals were assessed for STRESS-induced ANXIETY using the elevated plus maze and DEPRESSION using the forced swim test. Thereafter blood was withdrawn from the retro-orbital plexus and plasma separated, the brain was also isolated, homogenized, centrifuged, and the supernatant was obtained for biochemical estimation.Results: MORIN HYDRATE (5, 10, 20 mg/kg) produced a significant reduction in immobility time in the swimming endurance test, while significantly increased the anoxic STRESS tolerance time. Acute RESTRAINT STRESS caused a significant decrease in reduced glutathione levels (which was reversed by MORIN HYDRATE) and increased the level of malondialdehyde, a thiobarbituric acid reactive substance which is an index of oxidative STRESS and nitrite. These effects were attenuated by MORIN HYDRATE. Also, pretreatment with MORIN HYDRATE attenuates acute RESTRAINT STRESS-associated ANXIETY and DEPRESSION, reversed the hyperglycemia evoked by the STRESSful exposure and normalized serum cholesterol levels.Conclusion: These findings suggest that MORIN HYDRATE exhibits anti-stress effects and may be useful in the relief of STRESS.

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APA: Copy

OLONODE, ELIZABETH TOYIN, ADERIBIGBE, ADEGBUYI OLADELE, ADEOLUWA, OLUSEGUN ADEBAYO, & AJAYI, ABAYOMI MAYOWA. (2018). PROTECTIVE EFFECTS OF MORIN HYDRATE ON ACUTE STRESS-INDUCED BEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN MICE. BASIC AND CLINICAL NEUROSCIENCE, 9(3), 195-208. SID. https://sid.ir/paper/327872/en

Vancouver: Copy

OLONODE ELIZABETH TOYIN, ADERIBIGBE ADEGBUYI OLADELE, ADEOLUWA OLUSEGUN ADEBAYO, AJAYI ABAYOMI MAYOWA. PROTECTIVE EFFECTS OF MORIN HYDRATE ON ACUTE STRESS-INDUCED BEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN MICE. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2018;9(3):195-208. Available from: https://sid.ir/paper/327872/en

IEEE: Copy

ELIZABETH TOYIN OLONODE, ADEGBUYI OLADELE ADERIBIGBE, OLUSEGUN ADEBAYO ADEOLUWA, and ABAYOMI MAYOWA AJAYI, “PROTECTIVE EFFECTS OF MORIN HYDRATE ON ACUTE STRESS-INDUCED BEHAVIORAL AND BIOCHEMICAL ALTERATIONS IN MICE,” BASIC AND CLINICAL NEUROSCIENCE, vol. 9, no. 3, pp. 195–208, 2018, [Online]. Available: https://sid.ir/paper/327872/en

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