COMPARISON OF EFFECTS OF LIGHT ANESTHETICS, DIETHYL ETHER AND CARBON DIOXIDE, ON HYPOTHALAMIC PARAVENTRICULAR NUCLEUS D1 AND D2 DOPAMINE RECEPTORS- AND GLUCOSENSITIVE NEURONS- INDUCED FOOD INTAKE IN FASTED CONSCIOUS RATS

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SHAREGHI BROJENI MASOUD; SALIMI MORTEZA; Mirmohamadsadeghi Zahra; HAGHPARAST ABBAS; ELIASSI AFSANEH

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Journal: Basic and Clinical Neuroscience Year:2018 | Volume:9 | Issue:4 Page(s): 269-274

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Title

COMPARISON OF EFFECTS OF LIGHT ANESTHETICS, DIETHYL ETHER AND CARBON DIOXIDE, ON HYPOTHALAMIC PARAVENTRICULAR NUCLEUS D1 AND D2 DOPAMINE RECEPTORS- AND GLUCOSENSITIVE NEURONS- INDUCED FOOD INTAKE IN FASTED CONSCIOUS RATS

Author(s)

Keywords

CARBON DIOXIDE

DIETHYL ETHER

PARAVENTRICULAR NUCLEUS (PVN)

FOOD INTAKE

DOPAMINE RECEPTORS

GLUCOSENSING NEURONS

Abstract

Introduction: CARBON DIOXIDE (CO2) and DIETHYL ETHER are used as light anesthetics. However, experimental data about their side effects are scarce. In addition, in all our previous works on regulatory mechanisms of hypothalamus during FOOD INTAKE, including the effect of Paraventricular Nucleus (PVN) D1 and D2 DOPAMINE RECEPTORS and glucosensitive neurons, the drug injections were performed under brief DIETHYL ETHER anesthesia. In the current study, we tested the hypothesis which postulates that CO2 and DIETHYL ETHER as light anesthetic agents affect the stimulatory effect of PVN DOPAMINE RECEPTORS and glucosensitive neurons in feeding behavior.Methods: Male Wistar rats were implanted with guide cannula directed to their PVN. Glucose (0.8 mg), SKF38393 (D1 agonist, 0.5 mg), quinpirole (D2 agonist, 0.3 mg) and saline (0.3 L) were microinjected into the PVN and FOOD INTAKE was measured over 1 hour.Results: Our results showed that CO2 but not DIETHYL ETHER decreased FOOD INTAKE compared to intact animals. The PVN injections of glucose, SKF38393, and quinpirole increased FOOD INTAKE under brief DIETHYL ETHER anesthesia. In contrast, the PVN microinjected glucose-induced and dopamine receptor agonists-induced FOOD INTAKE were inhibited under light CO2 anesthesia.Conclusion: Our results suggest that brief exposure to CO2 and DIETHYL ETHER as light anesthetic agents may affect PVN GLUCOSENSING NEURONS-induced and DOPAMINE RECEPTORS-induced FOOD INTAKE in fasted rats.

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APA: Copy

SHAREGHI BROJENI, MASOUD, SALIMI, MORTEZA, Mirmohamadsadeghi, Zahra, HAGHPARAST, ABBAS, & ELIASSI, AFSANEH. (2018). COMPARISON OF EFFECTS OF LIGHT ANESTHETICS, DIETHYL ETHER AND CARBON DIOXIDE, ON HYPOTHALAMIC PARAVENTRICULAR NUCLEUS D₁ AND D₂ DOPAMINE RECEPTORS- AND GLUCOSENSITIVE NEURONS- INDUCED FOOD INTAKE IN FASTED CONSCIOUS RATS. BASIC AND CLINICAL NEUROSCIENCE, 9(4), 269-274. SID. https://sid.ir/paper/327898/en

Vancouver: Copy

SHAREGHI BROJENI MASOUD, SALIMI MORTEZA, Mirmohamadsadeghi Zahra, HAGHPARAST ABBAS, ELIASSI AFSANEH. COMPARISON OF EFFECTS OF LIGHT ANESTHETICS, DIETHYL ETHER AND CARBON DIOXIDE, ON HYPOTHALAMIC PARAVENTRICULAR NUCLEUS D₁ AND D₂ DOPAMINE RECEPTORS- AND GLUCOSENSITIVE NEURONS- INDUCED FOOD INTAKE IN FASTED CONSCIOUS RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2018;9(4):269-274. Available from: https://sid.ir/paper/327898/en

IEEE: Copy

MASOUD SHAREGHI BROJENI, MORTEZA SALIMI, Zahra Mirmohamadsadeghi, ABBAS HAGHPARAST, and AFSANEH ELIASSI, “COMPARISON OF EFFECTS OF LIGHT ANESTHETICS, DIETHYL ETHER AND CARBON DIOXIDE, ON HYPOTHALAMIC PARAVENTRICULAR NUCLEUS D₁ AND D₂ DOPAMINE RECEPTORS- AND GLUCOSENSITIVE NEURONS- INDUCED FOOD INTAKE IN FASTED CONSCIOUS RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 9, no. 4, pp. 269–274, 2018, [Online]. Available: https://sid.ir/paper/327898/en

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