The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration

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Jahanmahin Ahmad; ABBASNEJAD ZAHRA; HAGHPARAST ABBAS; AHMADIANI ABOLHASSAN; GHASEMI RASOUL

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Journal: Basic and Clinical Neuroscience Year:2019 | Volume:10 | Issue:1 Page(s): 23-36

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Title

The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration

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Keywords

Alzheimer Disease

Cholinergic neurons

Scopolamine

Mitogen-Activated Protein Kinases

Caspase-3

Apoptosis

Abstract

Introduction: It is well documented that insulin has neuroprotective and neuromodulator effects and can protect against different models of memory loss. Furthermore, cholinergic activity plays a significant role in memory, and Scopolamine-induced memory loss is widely used as an experimental model of dementia. The current study aimed at investigating the possible effects of insulin against Scopolamine-induced memory impairment in Wistar rat and its underlying molecular mechanisms. Methods: Accordingly, animals were bilaterally cannulated in CA1, hippocampus. Intrahippocampal administration of insulin 6 MU and 12 MU in CA1 per day was performed during first 6 days after surgery. During next four days, the animal’ s spatial learning and memory were assessed in Morris water maze test (three days of learning and one day of retention test). The animals received Scopolamine (1 mg/kg) Intraperitoneally (IP) 30 minutes before the onset of behavioral tests in each day. In the last day, the hippocampi were dissected and the levels of MAPK (Mitogen-Activated Protein Kinases) and Caspase-3 activation were analyzed by Western blot technique. Results: The behavioral results showed that Scopolamine impaired spatial learning and memory without activating casapase-3, P38, and JNK, but chronic pretreatment by both doses of insulin was unable to restore this spatial memory impairment. In addition, Scopolamine significantly reduced Extracellular signal-Regulated Kinases (ERKs) activity and insulin was unable to restore this reduction. Results revealed that Scopolamine-mediated memory loss was not associated with hippocampal damage. Conclusion: Insulin as a neuroprotective agent cannot restore memory when there is no hippocampal damage. In addition, the neuromodulator effect of insulin is not potent enough to overwhelm Scopolamine-mediated disruptions of synaptic neurotransmission.

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APA: Copy

Jahanmahin, Ahmad, ABBASNEJAD, ZAHRA, HAGHPARAST, ABBAS, AHMADIANI, ABOLHASSAN, & GHASEMI, RASOUL. (2019). The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration. BASIC AND CLINICAL NEUROSCIENCE, 10(1), 23-36. SID. https://sid.ir/paper/327907/en

Vancouver: Copy

Jahanmahin Ahmad, ABBASNEJAD ZAHRA, HAGHPARAST ABBAS, AHMADIANI ABOLHASSAN, GHASEMI RASOUL. The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2019;10(1):23-36. Available from: https://sid.ir/paper/327907/en

IEEE: Copy

Ahmad Jahanmahin, ZAHRA ABBASNEJAD, ABBAS HAGHPARAST, ABOLHASSAN AHMADIANI, and RASOUL GHASEMI, “The Effect of Intrahippocampal Insulin Injection on Scopolamine-induced Spatial Memory Impairment and Extracellular Signal-regulated Kinases Alteration,” BASIC AND CLINICAL NEUROSCIENCE, vol. 10, no. 1, pp. 23–36, 2019, [Online]. Available: https://sid.ir/paper/327907/en

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