INVOLVEMENT OF NITRIC OXIDE WITHIN THE VENTRAL TEGMENTAL AREA ON THE ‎ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE ‎PREFERENCE IN MORPHINE-SENSITIZED RATS

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FALAH A.; ZARINDAST M.R.; KHOUSHBATEN A.; SAHRAEI HEDAYAT

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Journal: KOWSAR MEDICAL JOURNAL Year:2007 | Volume:12 | Issue:2 Page(s): 107-115

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Title

INVOLVEMENT OF NITRIC OXIDE WITHIN THE VENTRAL TEGMENTAL AREA ON THE ‎ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE ‎PREFERENCE IN MORPHINE-SENSITIZED RATS

Author(s)

FALAH A. | ZARINDAST M.R. | KHOUSHBATEN A. | SAHRAEI HEDAYAT | Issue Writer Certificate

Keywords

L-ARGININEQ3

MORPHINE SENSITIZATIONQ3

NITRIC OXIDE (NO)Q3

L-NAMEQ3

VENTRAL TEGMENTAL AREAQ3

RATQ3

Abstract

Objective: In the present study, the effects of intra-ventral tegmental area administration of L-ARGININE, a nitric oxide precursor, and NG-nitro-L-ARGININE methyl-ester (L NAME), a nitric oxide synthase inhibitor, on the acquisition and expression of morphine-induced place conditioning in morphine-sensitized RATs were studied. Materials and Methods: Subcutaneous (s.c.) administration of morphine (5 mg/kg) induced conditioned place preference. Repeated pretreatment of morphine (5 mg/kg, s.c.) followed by 5 days no drug treatment, increased conditioning response induced by morphine (0.5 mg/kg, s.c.).Results: Intra-ventral tegmental area administration of L-ARGININE (0.01, 0.1 and 0.3 mg/rat) has no effect on the acquisition and/or expression of morphine place conditioning in non-sensitized and sensitized RATs. Intra-ventral tegmental area injections of L-NAME (0.1 mg/rat) reduced the expression but not the acquisition of morphine place conditioning in the sensitized animals. Conclusion: The results indicate that nitric oxide (NO) within the VENTRAL TEGMENTAL AREA is not involved in the acquisition and expression of morphine place conditioning in morphine-sensitized RATs.

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APA: Copy

FALAH, A., ZARINDAST, M.R., KHOUSHBATEN, A., & SAHRAEI, HEDAYAT. (2007). INVOLVEMENT OF NITRIC OXIDE WITHIN THE VENTRAL TEGMENTAL AREA ON THE ‎ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE ‎PREFERENCE IN MORPHINE-SENSITIZED RATS. KOWSAR MEDICAL JOURNAL, 12(2), 107-115. SID. https://sid.ir/paper/32819/en

Vancouver: Copy

FALAH A., ZARINDAST M.R., KHOUSHBATEN A., SAHRAEI HEDAYAT. INVOLVEMENT OF NITRIC OXIDE WITHIN THE VENTRAL TEGMENTAL AREA ON THE ‎ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE ‎PREFERENCE IN MORPHINE-SENSITIZED RATS. KOWSAR MEDICAL JOURNAL[Internet]. 2007;12(2):107-115. Available from: https://sid.ir/paper/32819/en

IEEE: Copy

A. FALAH, M.R. ZARINDAST, A. KHOUSHBATEN, and HEDAYAT SAHRAEI, “INVOLVEMENT OF NITRIC OXIDE WITHIN THE VENTRAL TEGMENTAL AREA ON THE ‎ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE ‎PREFERENCE IN MORPHINE-SENSITIZED RATS,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 2, pp. 107–115, 2007, [Online]. Available: https://sid.ir/paper/32819/en

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