THE EFFECT OF NITRIC OXIDE ON THE ACQUISITION AND EXPRESSION OF NICOTINEINDUCED PLACE PREFERENCE IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHOSHOUNI H.; SAHRAEI HEDAYAT; FALAHI M.; SABET KASAEI M.; ZARINDAST M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2003 | Volume:6 | Issue:2 Page(s): 209-220

Download Full-Text

Persian Verion

View:

731

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF NITRIC OXIDE ON THE ACQUISITION AND EXPRESSION OF NICOTINEINDUCED PLACE PREFERENCE IN MICE

Author(s)

Keywords

NICOTINEQ3

NITRIC OXIDEQ3

CONDITIONED PLACE PREFERENCEQ4

MICEQ3

Abstract

It has been reported that NICOTINE induces many of its effects via increasing the production of NITRIC OXIDE (NO). In the present study, the possible role of NO in the induction of rewarding effects of NICOTINE was investigated, using CONDITIONED PLACE PREFERENCE (CPP) in male Swiss-Webster MICE (20-25 g). The results showed that injection of NICOTINE (0.25-2 mg/Kg, i.p.) and L-arginine (NO precursor) (50-500 mg/Kg, i.p.), but not mecamylamine (0.05 and 0.1 mg/Kg, i.p.) and L-NAME (nitric oxide synthase inhibitor) (5-20 mg/Kg, i.p.) to the animals produced a significant but not dose-dependent CPP. Administration of mecamylamine (0.05 and 0.1 mg/Kg, i.p.) or L-NAME (5-20 mg/kg, i.p.) before NICOTINE (1. mg/Kg, i.p.) or L arginine (200 mg/Kg, i.p.) significantly abolished the CPP induced by above-mentioned drugs. When the antagonists were administered 15 min before the test to those animals which received NICOTINE (1 mg/Kg, i.p.) or L-arginine (200 mg/Kg, i.p.) in the training days, the effects of the agonists did not change. Administration of ineffective doses of L-arginine (50, 100 and 150 mg/Kg, i.p.) in combination with ineffective dose of NICOTINE (0.6 mg/Kg, i.p.) potentiated the epp induced by NICOTINE. However, injection of L-arginine at these doses in the test day to those animals which received NICOTINE (1 mg/Kg) in training days reduced the response to the NICOTINE. The same results were obtained when ineffective doses of NICOTINE (0.25, 0.5 and 0.75 mg/Kg, i.p.) were administered with ineffective dose of L-arginine (50 mg/Kg, i.p.). Furthermore, NICOTINE (0.25, 0.5 and 0.75 mg/Kg) when administered before the test to those animals which received L-arginine (200 mg/Kg) in the training days reduced the expression of epp induced by L-arginine. In conclusion, it can be suggested that NO may play an important role in NICOTINE rewarding effects as investigated by CPP paradigm.

Cites

No record.

References

No record.

Cite

APA: Copy

GHOSHOUNI, H., SAHRAEI, HEDAYAT, FALAHI, M., SABET KASAEI, M., & ZARINDAST, M.R.. (2003). THE EFFECT OF NITRIC OXIDE ON THE ACQUISITION AND EXPRESSION OF NICOTINEINDUCED PLACE PREFERENCE IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 6(2), 209-220. SID. https://sid.ir/paper/75100/en

Vancouver: Copy

GHOSHOUNI H., SAHRAEI HEDAYAT, FALAHI M., SABET KASAEI M., ZARINDAST M.R.. THE EFFECT OF NITRIC OXIDE ON THE ACQUISITION AND EXPRESSION OF NICOTINEINDUCED PLACE PREFERENCE IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2003;6(2):209-220. Available from: https://sid.ir/paper/75100/en

IEEE: Copy

H. GHOSHOUNI, HEDAYAT SAHRAEI, M. FALAHI, M. SABET KASAEI, and M.R. ZARINDAST, “THE EFFECT OF NITRIC OXIDE ON THE ACQUISITION AND EXPRESSION OF NICOTINEINDUCED PLACE PREFERENCE IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 6, no. 2, pp. 209–220, 2003, [Online]. Available: https://sid.ir/paper/75100/en

Related Journal Papers