SURVIVAL RATE AND CELL MEDIATED IMMUNITY OF BALB/C MICE IMMUNIZED WITH EXCRETORY SECRETORY ANTIGENS OF TOXOPLASMAGONDII

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DARYANI A.; ZAVARAN HOSSEINI A.; DALIMIASL A.A.H.

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Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:5 | Issue:4 Page(s): 281-288

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Title

SURVIVAL RATE AND CELL MEDIATED IMMUNITY OF BALB/C MICE IMMUNIZED WITH EXCRETORY SECRETORY ANTIGENS OF TOXOPLASMAGONDII

Author(s)

DARYANI A. | ZAVARAN HOSSEINI A. | DALIMIASL A.A.H. | Issue Writer Certificate

Keywords

TOXOPLASMA GONDIIQ4

CELL MEDIATED IMMUNITYQ4

EXCRETORY SECRETORY ANTIGENSQ4

BALB/C MICEQ4

Abstract

In the present study EXCRETORY SECRETORY ANTIGENS (ESA) of TOXOPLASMA GONDII were evaluated in immunization of 8-10 week inbred female BALB/C MICE. Tachyzoites of the parasite were cultured in cell-free incubation medium (RPMI-1640), then supernatant of the medium was loaded in ion exchange chromatography column. Two fractions (ESA-F1 and ESA-F2) were collected from the column. For immunization of the mice, 50 mice were allocated into 5 groups, each group 10 mice. The first, second, third and the fourth group were immunized, 2 times with total-ESA, ESA-F1, ESA-F2 or toxoplasma lysate antigen (TLA) respectively. The fifth group was selected as negative control group (non-immunized). The virulent RH strain of TOXOPLASMA GONDII was used for challenging. The results indicated that Total-ESA, ESA-F1 and ESA-F2 in the immunized mice resulted in a delayed-type hypersensitivity reaction (DTH) and lymphocyte transformation responses. All non-immunized mice died within 10 days, whereas immunized mice survived for longer time (P>0.05). The highest survival rate was observed in mice that received ESA-F2. We suggest that these antigens, specially ESA-F2, should be valuable for the development of new strategies for immunization against toxoplasmosis.

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APA: Copy

DARYANI, A., ZAVARAN HOSSEINI, A., & DALIMIASL, A.A.H.. (2001). SURVIVAL RATE AND CELL MEDIATED IMMUNITY OF BALB/C MICE IMMUNIZED WITH EXCRETORY SECRETORY ANTIGENS OF TOXOPLASMAGONDII. KOWSAR MEDICAL JOURNAL, 5(4), 281-288. SID. https://sid.ir/paper/32839/en

Vancouver: Copy

DARYANI A., ZAVARAN HOSSEINI A., DALIMIASL A.A.H.. SURVIVAL RATE AND CELL MEDIATED IMMUNITY OF BALB/C MICE IMMUNIZED WITH EXCRETORY SECRETORY ANTIGENS OF TOXOPLASMAGONDII. KOWSAR MEDICAL JOURNAL[Internet]. 2001;5(4):281-288. Available from: https://sid.ir/paper/32839/en

IEEE: Copy

A. DARYANI, A. ZAVARAN HOSSEINI, and A.A.H. DALIMIASL, “SURVIVAL RATE AND CELL MEDIATED IMMUNITY OF BALB/C MICE IMMUNIZED WITH EXCRETORY SECRETORY ANTIGENS OF TOXOPLASMAGONDII,” KOWSAR MEDICAL JOURNAL, vol. 5, no. 4, pp. 281–288, 2001, [Online]. Available: https://sid.ir/paper/32839/en

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