EFFICACY OF BOTULINUM TOXIN TYPE A FOR TREATING CHRONIC LOW BACK PAIN

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MOGHTADERI ALI REZA; LOGHMANI AMIR

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Journal: Anesthesiology and Pain Medicine Year:2011 | Volume:1 | Issue:2 (2) Page(s): 77-80

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Title

EFFICACY OF BOTULINUM TOXIN TYPE A FOR TREATING CHRONIC LOW BACK PAIN

Author(s)

MOGHTADERI ALI REZA | LOGHMANI AMIR | Issue Writer Certificate

Keywords

BOTULINUM TOXIN TYPE A

LOW BACK PAIN

PAIN

Abstract

Background: PAIN/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> LOW BACK PAIN is a major cause of disability and can result in substantial morbidity and high healthcare costs. Botulinum toxin has been used successfully to alleviate PAIN for a number of conditions caused by muscle contractions or spasms.Objectives: The aim of this study was to investigate the efficacy of BOTULINUM TOXIN TYPE A (BoNT-A; Dysport®, Ipsen, UK) for treating chronic PAIN/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> LOW BACK PAIN (CLBP).Patients and Methods: This was a single-blind, randomized clinical trial study. Fifty patients with CLBP received either BoNT-A (40 Ipsen units per injection) or saline in 5 sites in the paraspinal muscles (n=25 per group). A visual analogue system (VAS) was used to measure PAIN levels at baseline and at 4 and 8 weeks post-injection. Disability was assessed using the Oswestry PAIN/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> LOW BACK PAIN disability questionnaire at baseline and at 8 weeks post-injection.Results: After 4 weeks, 76% of patients in the BoNT-A group reported PAIN relief compared to 20% in the saline group (P<0.005). Additionally, greater PAIN relief was experienced by patients in the BoNT-A group at 8 weeks (64% vs.12%; P<0.001). By week 8, significant functional improvement (a minimum two-grade improvement between baseline and post-treatment assessments) was demonstrated in a higher number of patients receiving BoNT-A than in the saline group (68% vs.12%, respectively; P<0.005). Patients experienced only minor side effects.Conclusions: BoNT-A improves CLBP with a low incidence of side effects and can be used as a therapeutic tool in the management of these patients.

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APA: Copy

MOGHTADERI, ALI REZA, & LOGHMANI, AMIR. (2011). EFFICACY OF BOTULINUM TOXIN TYPE A FOR TREATING CHRONIC LOW BACK PAIN. ANESTHESIOLOGY AND PAIN MEDICINE, 1(2 (2)), 77-80. SID. https://sid.ir/paper/328392/en

Vancouver: Copy

MOGHTADERI ALI REZA, LOGHMANI AMIR. EFFICACY OF BOTULINUM TOXIN TYPE A FOR TREATING CHRONIC LOW BACK PAIN. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2011;1(2 (2)):77-80. Available from: https://sid.ir/paper/328392/en

IEEE: Copy

ALI REZA MOGHTADERI, and AMIR LOGHMANI, “EFFICACY OF BOTULINUM TOXIN TYPE A FOR TREATING CHRONIC LOW BACK PAIN,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 1, no. 2 (2), pp. 77–80, 2011, [Online]. Available: https://sid.ir/paper/328392/en

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