ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN SEVERE PREECLAMPSIA: RELATIVE EFFICACIES OF NITROGLYCERINE INFUSION, SUBLINGUAL NIFEDIPINE, AND INTRAVENOUS HYDRALAZINE

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SAFAVI MOHAMMADREZA; HONARMAND AZIM; AZARI NEDA

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Journal: Anesthesiology and Pain Medicine Year:2011 | Volume:1 | Issue:2 (2) Page(s): 81-89

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Title

ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN SEVERE PREECLAMPSIA: RELATIVE EFFICACIES OF NITROGLYCERINE INFUSION, SUBLINGUAL NIFEDIPINE, AND INTRAVENOUS HYDRALAZINE

Author(s)

SAFAVI MOHAMMADREZA | HONARMAND AZIM | AZARI NEDA | Issue Writer Certificate

Keywords

PREECLAMPSIA

CESAREAN SECTION

NIFEDIPINE

HYDRALAZINE

NITROGLYCERINE

Abstract

Background: The pressor response to laryngoscopy is known to be exaggerated in patients with severe PREECLAMPSIA.Objectives: The aim of the present study was to compare the efficacies of continuous intravenous (IV) infusion of NITROGLYCERINE, IV HYDRALAZINE, or sublingual NIFEDIPINE in modifying cardiovascular responses to endotracheal intubation, in women with severe PREECLAMPSIA undergoing cesarean delivery under general anesthesia.Patients and Methods: A total of 120 patients undergoing cesarean delivery were randomly divided into 3 groups, each receiving one of the following drugs before intubation: 5 μg/min NITROGLYCERINE administered by continuous IV infusion (Group NTG, n= 40); a 10-mg capsule of NIFEDIPINE deposited sublingually (Group NIF, n=40); or 5–0 mg HYDRALAZINE intravenously (Group H, n=40). Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP) were simultaneously recorded in the mother at pre-induction, pre-intubation, and at 1, 3, 5, and 10 min after intubation.Results: In contrast to those in group NIF and group H, the patients in group NTG showed no significant increases in HR, SAP, DAP, or MAP after intubation, compared to baseline. The incidence of hypotension was significantly greater in group NIF than in group H or group NTG [15 (37.5%) vs.8 (20%) vs.5 (12.5%) respectively, P=0.025].Conclusions: In patients with severe PREECLAMPSIA undergoing cesarean delivery, a continuous IV infusion of NITROGLYCERINE was able to attenuate the cardiovascular response to intubation to a greater extent than the use of sublingual NIFEDIPINE or IV HYDRALAZINE, without significant adverse effects on the newborn.

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APA: Copy

SAFAVI, MOHAMMADREZA, HONARMAND, AZIM, & AZARI, NEDA. (2011). ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN SEVERE PREECLAMPSIA: RELATIVE EFFICACIES OF NITROGLYCERINE INFUSION, SUBLINGUAL NIFEDIPINE, AND INTRAVENOUS HYDRALAZINE. ANESTHESIOLOGY AND PAIN MEDICINE, 1(2 (2)), 81-89. SID. https://sid.ir/paper/328395/en

Vancouver: Copy

SAFAVI MOHAMMADREZA, HONARMAND AZIM, AZARI NEDA. ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN SEVERE PREECLAMPSIA: RELATIVE EFFICACIES OF NITROGLYCERINE INFUSION, SUBLINGUAL NIFEDIPINE, AND INTRAVENOUS HYDRALAZINE. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2011;1(2 (2)):81-89. Available from: https://sid.ir/paper/328395/en

IEEE: Copy

MOHAMMADREZA SAFAVI, AZIM HONARMAND, and NEDA AZARI, “ATTENUATION OF THE PRESSOR RESPONSE TO TRACHEAL INTUBATION IN SEVERE PREECLAMPSIA: RELATIVE EFFICACIES OF NITROGLYCERINE INFUSION, SUBLINGUAL NIFEDIPINE, AND INTRAVENOUS HYDRALAZINE,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 1, no. 2 (2), pp. 81–89, 2011, [Online]. Available: https://sid.ir/paper/328395/en

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