EFFICACY OF ELAEAGNUS ANGUSTIFOLIA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ALI SHIRI GH.H.; AHMADIANI A.; BAYAT NOUSHIN; KAMALINEZHAD M.; SALIMZADEH A.; SAREMI S.; MIRI M.; NOUDEH A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2007 | Volume:12 | Issue:1 Page(s): 49-57

Download Full-Text

Persian Verion

View:

5,040

Download:

Cites:

Information Journal Paper

Title

EFFICACY OF ELAEAGNUS ANGUSTIFOLIA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL

Author(s)

Keywords

KNEE OSTEOARTHRITISQ3

TREATMENTQ3

ELAEAGNUS ANGUSTIFOLIAQ3

ACETAMINOPHENQ3

Abstract

Introduction: The TREATMENT of osteoarthritis (OA), a disease affecting the majority of the elderly population, involves the alleviation of symptoms, such as pain and stiffness, and the reduction of inflammation.Objectives: To evaluate the efficacy of ELAEAGNUS ANGUSTIFOLIA (EA) extract tablets in the TREATMENT of patients with osteoarthritis of the knee, compared with ACETAMINOPHEN and a control group administered placebo tablets.Material and Methods: In this study, 120 patients with OA of the knee and with moderate to severe pain, with no significant concomitant disorders, and with matching age, sex, BMI, and Kellgren-Lawrence grades were studied in a randomized placebo-controlled double-blind 7-week trial. The trial consisted of a 2-week washout period followed by three different TREATMENT plans, with 40 patients receiving ELAEAGNUS ANGUSTIFOLIA extract, 40 patients receiving a placebo, and 40 patients administered ACETAMINOPHEN, each with a dosage of 2 tablets per day. Patients with severe pain, permitted using naproxen as rescue medication throughout the study. The evaluation of the results consisted of visual analogue scale (VAS) pain assessment, Lequesne’s Pain-Function Index (LPFI), and patient and physician global Assessment of efficacy and tolerability by patient and physician.Results: 115 patients were evaluated for 7 weeks; 38 patients received EA; 37 received ACETAMINOPHEN; 40 received placebo. The mean±SD LPFI score decreased from 9.3±2.6 to 6.7±3.1 in the EA group and from 10.4±2.8 to 8.6±2.9 in the ACETAMINOPHEN group and from 9.4±2.9 to 8.3±2.9 in the placebo group (P<0.001). Pain decreased from 40.8±17.8 to 23.2±15.4 in the EA group and from 37.4±18.6 to 27.8±19.6 in the ACETAMINOPHEN group, and from 42.6±13.5 to 41.6±12.7 in the placebo group at week 7 (P<0.001). For patient and physician global assessment, improvements from baseline in EA groups were superior to the ACETAMINOPHEN and placebo groups (P<0.001). No clinically or statistically significant differences were seen in adverse events or tolerability among the study groups.Conclusion: This study showed that ELAEAGNUS ANGUSTIFOLIA extract, a new herbal remedy, provides significant efficacy over a cetaminophen and placebo in TREATMENT of OA of the knee.

Cites

No record.

References

No record.

Cite

APA: Copy

ALI SHIRI, GH.H., AHMADIANI, A., BAYAT, NOUSHIN, KAMALINEZHAD, M., SALIMZADEH, A., SAREMI, S., MIRI, M., & NOUDEH, A.A.. (2007). EFFICACY OF ELAEAGNUS ANGUSTIFOLIA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL. KOWSAR MEDICAL JOURNAL, 12(1), 49-57. SID. https://sid.ir/paper/32846/en

Vancouver: Copy

ALI SHIRI GH.H., AHMADIANI A., BAYAT NOUSHIN, KAMALINEZHAD M., SALIMZADEH A., SAREMI S., MIRI M., NOUDEH A.A.. EFFICACY OF ELAEAGNUS ANGUSTIFOLIA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL. KOWSAR MEDICAL JOURNAL[Internet]. 2007;12(1):49-57. Available from: https://sid.ir/paper/32846/en

IEEE: Copy

GH.H. ALI SHIRI, A. AHMADIANI, NOUSHIN BAYAT, M. KAMALINEZHAD, A. SALIMZADEH, S. SAREMI, M. MIRI, and A.A. NOUDEH, “EFFICACY OF ELAEAGNUS ANGUSTIFOLIA EXTRACT IN TREATMENT OF OSTEOARTHRITIS OF KNEE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 1, pp. 49–57, 2007, [Online]. Available: https://sid.ir/paper/32846/en

Related Journal Papers